Stem cell transplants can cure patients with high-risk leukemia or lymphoma. Graft-versus-host disease (GVHD) is a potentially life-threatening side effect that occurs when the donor's immune cells attack the recipient's normal tissues. Moffitt Cancer Center researchers are trying to identify new drug targets to reduce the risk of GVHD. Their new study, published in the Proceedings of the National Academy of Sciences, shows a drug that targets the protein JAK2 may reduce the risk of GVHD.
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The systematic review was conducted with the first objective aimed at providing an overview of the physiological characteristics commonly evaluated in rugby and the corresponding tests used to measure each construct. Secondly, the measurement properties of all identified tests per physiological construct were evaluated with the ultimate purpose of identifying tests with the strongest level of evidence per construct.
In the general population, adiposity influences erythropoiesis and iron metabolism. Researchers aimed at assessing the relationship between adiposity [estimated by body mass index ( BMI ) and abdominal circumference ( AC )] and biomarkers of erythropoiesis in patients with chronic kidney disease ( CKD ) not on dialysis .
In this study, researchers evaluated in terms of outbreaks in Indonesia. A deadly measles-and-malnutrition outbreak that killed scores of children in Indonesia's remote Papua province is over. According to statistics showed a total of 72 children died while hundreds more were sickened because of the "extraordinary" outbreak, which hit several isolated communities in Papua's Asmat district between September 2017 and February 4.
Twenty-five years ago, an unusual inherited form of high blood pressure was first described in an Australian family. Its genetic cause, however, had remained elusive. Using modern sequencing methods, an international research team led by BIH Johanna Quandt Professor Ute Scholl has succeeded in detecting mutations in a new disease gene (CLCN2), present in this family and seven others that are responsible for the development of a familial form of hyperaldosteronism .
Opioid cessation in non-cancer pain may be more successful when depression is treated to remission, according to a study published in the February issue of the British Journal of Psychiatry.
A new study published in the PLoS One has reported that general practitioners (GPs) had distinct attitudes toward psychotherapy, falling into three different categories according to their opinions of this type of treatment. The majority of general practitioners (GPs) were reasonably favourable to psychotherapy.
Researchers evaluate the association between Trypanosoma cruzi infection and strongyloidiasis in a cohort of Latin American (LA) migrants screened for both infections in a non-endemic setting.
A new discovery sheds new light on the pathology of Alzheimer's disease (AD) as well as on the communication between the brain and the rest of the body. An association between inflammation biomarkers in both blood plasma and cerebrospinal fluid (CSF) and markers of AD-associated pathology. The findings were published today in the Journal of Alzheimer's Disease.
Researchers observed that these proteins move extremely slowly in the plasma membrane of the yeast and discovered how they travel through the membrane to reach the islands. They made these observations with state-of-the-art super-resolution optical microscopy. These membrane compartments appear to store transport proteins. The study is published in Natural communications.
Bisphosphonates provide no significant benefit over placebo in patients with knee osteoarthritis (OA) with regard to pain relief, functional improvement, or prevention of radiographic progression, according to a meta-analysis published in Osteoarthritis and Cartilage.