According to a new study published in the Journal of the American Board of Family Medicine, commonly used antidepressant medications (ADMs) were not associated with incident hypertension after controlling for other factors associated with ADM use and hypertension. Research on potential dose and duration effects is warranted.
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A new study, published in the journal Science, has found that psychiatric disorders including schizophrenia, autism, and bipolar disorder share common molecular characteristics, despite showing distinct variations in gene expression.
Hybrid-capture sequencing is the method of choice for sequencing actionable gene mutations across the most common forms of lymphoid cancer, according to a new study published in The Journal of Molecular Diagnostics. It reliably identifies potentially actionable gene mutations in 91% of patients. This assay will bring the benefits of precision diagnosis and individualized therapy to patients with lymphoid cancer.
Inhibiting HDAC6 improves the structural stability of cells and protects against neuronal damage. Leuven research uncovered that targeting this mechanism could be a promising therapeutic approach for peripheral neuropathies, whether due to Charcot-Marie-Tooth disease (CMT) or as a side effect of chemotherapy.
Researchers have revealed that care discussions with older patients with chronic kidney disease (CKD) do not routinely include the topic of conservative management. The study findings were published in the American Journal of Kidney Diseases.
In this study, researchers recommend that higher yogurt intake is associated with lower cardiovascular disease risk among hypertensive men and women. High blood pressure is a major cardiovascular disease risk factor. Clinical trials have previously demonstrated beneficial effects of dairy consumption on cardiovascular health. Yogurt may independently be related to cardiovascular disease risk. The study published in the American Journal of Hypertension.
Creating an artificial implantable kidney would be an epic advance in medicine and could address a chronic shortage of donor kidneys needed for transplant. Researchers have been at this quest for the past 15 years and keep coming upon one extremely knotty problem: how to keep the blood flowing smoothly through the artificial device without clotting. In such devices, as blood platelets respond to mechanical forces, they have a natural tendency to clot, causing a device malfunction.
A major challenge in developing liver cancer drugs is that preclinical testing occurs in tumor models that do not accurately reflect human tumor features. Now, Singaporean researchers have grown organoids from liver tumors on specially engineered 3-D scaffolds. These organoids replicate important features of the original tumor, including genetic changes and intra-tumor heterogeneity, and could serve as tumor avatars for high-throughput drug screening.
The risk of invasive breast cancer is increased in postmenopausal women with a normal body mass index ( BMI ) but higher levels of body fat, meaning that a large portion of the population has an unrecognized risk of developing cancer. In addition, a lower level of physical activity was found in women with a normal BMI and higher amounts of body fat.
According to this study, researchers proposed that swarms of flies can be used to help monitor disease outbreaks. This follows their research that shows how whole communities of bacteria known as a microbiome. This bacterium can "hitch a ride" on common carrion flies and can be transferred to any surface where the flies land. The study is published in Scientific Reports.
The researchers found that a mother's weight status during the first half of gestation is "a key determinant of infant birth weight and highlight [s] the importance of the timing of weight gain in pregnancy." The study findings were published in the JAMA Pediatrics
The present study describes qualitative research, conducted in 2013, that may help to guide ongoing efforts to improve immunization coverage for some areas of India that have experienced persistently low coverage levels. Researchers collaborated to conduct the study utilizing the RED indicators to assess strengths and weaknesses of immunization services in select PHCs located in Gujarat, India.