All news from Anaesthesiology

CRISPR Screen Identifies Gene Against Flavivirus Infection

Researchers now report the first use of CRISPR genome-wide screening to identify a gene that helps cells resist flavivirus infection. UT Southwestern researchers today report the first use of CRISPR genome-wide screening to identify a gene that helps cells resist flavivirus infection. That nasty class of pathogens includes West Nile virus, dengue fever, Zika virus, and yellow fever.

Hypertrophic Cardiomyopathy Related to Sudden Death, Findings

About one person out of 500 has a heart condition known as hypertrophic cardiomyopathy (HCM). This condition causes thickening of the heart muscle and results in defects in the heart's electrical system. Under conditions of environmental stress such as exercise, HCM can result in sudden death. In other cases, patients may go undiagnosed, with their heart function declining gradually over decades. The study, published in Nature Biomedical Engineering

Promising Approach Against Acne, Laboratory Studies

Topical retinoids, which target retinoic acid receptors, are commonly used to treat acne. New research published in the British Journal of Dermatology reveals that trifarotene, a fourth-generation retinoid with potent and selective activity against only one particular retinoic acid receptor, may have an improved efficacy and safety profile compared with less selective retinoids. To characterize the in vitro metabolism and the pharmacology of the novel retinoid trifarotene.