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Examining Mineralising Tissues by Electron Microscopy

In this study, researchers determined the macro- and micro-structures of mineralised tissues hierarchy are well described and understood. Examination of their nanostructure is limited due to the intrinsic complexity of biological systems. Preceding transmission electron microscopy studies investigating mineralising tissues have not resolved fully the initial stages of mineral nucleation and growth within the collagen fibrils.

Lab-grown Cerebellar Cells Yield Clues to ASD

In a new study published in the journal Molecular Psychiatry, researchers at Boston Children's Hospital used stem cell technology to create cerebellar cells known as Purkinje cells from patients with tuberous sclerosis complex (TSC), a genetic syndrome that often includes autism spectrum disorder (ASD)-like features. In the lab, the cells showed several characteristics that may help explain how ASD develops at the molecular level.