All news from Anaesthesiology

Transcription Factor Opens Genome for T cell Development

In the new study published in Immunity, researchers from the Perelman School of Medicine at the University of Pennsylvania, describe the role of a transcription factor called TCF-1 in targeting the condensed chromatin and regulating the availability of genome sequences in T-cell development. The new connection between TCF-1 and chromatin will aid in developing new therapies using epigenetic drugs to alter T-cell fate in cancer, autoimmune disorders, and infectious diseases.

To Examine the Healing Effect Of 1?-Hydroxyvitamin D3 on BPPV

In this study, researchers investigated the healing effect of 1α-hydroxyvitamin D3 on the benign paroxysmal positional vertigo (BPPV). This is a kind of clinically common peripheral vestibular disease, which has the highest incidence rate in vertigo derived from the inner ear. Its main manifestation is that the transient paroxysmal vertigo can be caused when the head moves to a specific position, accompanied by nystagmus and autonomic neural symptoms.

Insulin Is Mediated by A Cell-Surface Receptor

In this study, researchers assessed the engagement with its cell-surface receptor and the resulting conformational change, which propagates across the plasma membrane to the intracellular module, remains poorly understood. They recognized for the first time in the visualization of the insulin receptor activation. This study is published in the ‘Journal of Cell Biology’.

Cancer Pioneer Employs Physics to Approach Cancer

In the cover article of Oncotarget, James Frost, Kenneth Pienta, MD, and the late Donald Coffey, Ph.D., use a theory of physical and biophysical symmetry to derive a new conceptualization of cancer. Co-author Dr. Coffey, ex-deputy director of the Johns Hopkins Kimmel Cancer Center and Professor of Urology, died before this paper was published at 85.