The genetic cause behind a strain of typhoid's resistance to five classes of antibiotics has been uncovered by scientists at the Wellcome Sanger Institute and their collaborators at Public Health England and Aga Khan University, Pakistan. The results, published in mBio suggest that treatment options are running out for typhoid, and there is an urgent need for preventative strategies including vaccines.
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A team of researchers has produced 3-D images from 129 individual molecules of flexible DNA origami particles. Their work provides the first experimental verification of the theoretical model of DNA origami. Over the past decade, researchers have been working to create nanoscale materials and devices using DNA as construction materials through a process called "DNA origami." The study has published in Nature Communications.
Postnatal depression (PND) is well-known to have an adverse effect on mothers' relationships with their children. Now, a study published in the PeerJ has found that PND continues to impact mother-child relationships into later life and affects multi-generational relationships too.
Two novel ocular hypotensive agents that have just been approved for use in humans — netarsudil and latanoprostene bunod — greatly reduce intraocular pressure, with lasting results in various animal models of glaucoma and in humans. Two articles that highlight these two breakthrough drugs published in the special issue of Journal of Ocular Pharmacology and Therapeutics.
In a study published in Annals of the Rheumatic Diseases, an international team has successfully tested a molecule inhibitor of interleukin-18, a protein involved in immune response. These encouraging results in terms of safety and efficacy are paving the way for a new kind of treatment, not only for Still's disease, but other rare inflammatory diseases, too.
Among patients who underwent total hip or total knee arthroplasty, aspirin did not differ significantly from rivaroxaban (Xarelto, Janssen Pharmaceutica) for prevention of proximal deep-vein thrombosis or pulmonary embolism, after both groups received a 5-day course of rivaroxaban immediately after surgery, a large trial found.
According to results from a retrospective study, functional and anatomical outcomes are similar after treatment with yellow micropulse (MP) laser or half-dose verteporfin photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSCR)
Scientists have established that the new neurons produced in adults react preferentially to reward-related sensory stimuli and help speed up the association between sensory information and reward. Adult-born neurons therefore play an important role in both the identification of a sensory stimulus and the positive value associated with that sensory experience. This stuyd has published in Proceedings of the National Academy of Sciences (PNAS).
Almost all cells in the human body have identical DNA sequences, yet there are 200-plus cell types with different sizes, shapes, and chemical compositions. Determining what parts of the genome are read to make protein and which are silenced is orchestrated by proteins called transcription factors. These regulate the availability of distinct stretches of DNA to be expressed as opposed to others that remain buried in tightly coiled structures called chromatin.
Digital health has a great potential towards reducing inequity in provisioning and distribution of healthcare resources and services, said J P Nadda, Union Minister for Health and Family Welfare, at the Global Digital Health Partnership Symposium in Sydney, Australia, today.
A systematic review of studies, published in PLOS ONE, focused on stroke survivors' and carers' experiences of primary care and community healthcare services has found that they feel abandoned because they have become marginalized by services and do not have the knowledge or skills to re-engage.
As the findings and subsequent news coverage regarding concussions and brain damage in football, we have all become aware that playing the game may involve more than living with painful injuries – it may involve incurring other life-threatening health problems that develop in later life.