All news from Anaesthesiology

Evaluate CT Scans For Head Trauma Patients In Emergency Department

According to a study presented at the ARRS 2018 Annual Meeting, set for April 22-27 in Washington, DC. The study evaluated head CT scans executed for minor head injury (MHI) in patients aged 18-45 who presented to the hospital's emergency department. Emergency patients are too often given head CT to check for skull fractures and brain hemorrhage, leading to unnecessary heath care costs and patient exposure to radiation,

Evaluate Hemodynamic Interventions Improves Survival in Adults With Sepsis

The Severe Sepsis and Septic Shock Early Management Bundle (SEP-1), the sepsis performance measure introduced by the Centers for Medicare & Medicaid Services (CMS), requires up to 5 hemodynamic interventions, as many as 141 tasks, and 3 hours to document for a single patient. To evaluate whether moderate- or high-level evidence shows that use of SEP-1 or its hemodynamic interventions improves survival in adults with sepsis.

Urinary Incontinence: Tension-Free Vaginal Tape was Effective

The aim of the present study was to report the long-term subjective and objective outcomes of women who underwent an R-TVT procedure with a minimum 17-year follow-up, to assess the efficacy and the safety of this procedure. We also sought to investigate the predictive factors potentially involved in the risk of recurrence of SUI and the onset of de novo overactive bladder (OAB).

PharmaMar licenses Fully Synthetic Marine-Derived Payloads to Seattle Genetics

PharmaMar (MSE: PHM) has announced today the signing of an exclusive licensing agreement with Seattle Genetics Inc. (SGEN: NASDAQ GS) for fully synthetic marine-derived payloads for use in drug conjugates.

Under which Seattle Genetics receives exclusive worldwide rights to certain PharmaMar proprietary molecules for the development, manufacture, and commercialization of antibody-drug conjugates and/or other drug conjugates incorporating PharmaMar payloads.

Haloperidol: Delirium or survival rates in ICU patients Remain Uneffected

Prophylactic use of the drug haloperidol does not help to prevent delirium in intensive care patients or improve their chances of survival. Therefore, there is no reason anymore to administer the drug as a preventive measure to reduce the burden of delirium.

This was revealed following a three-year, large-scale study among 1,800 patients in 20 Dutch ICUs, headed by Radboud university medical center. The results of this world's largest research project into delirium prevention in the ICU have been published in the Journal of the American Medical Association (JAMA).

To Examine Abnormally Expressed lncRNAs And In Vocal Cord Leukoplakia

In this study, researchers used microarrays to investigate the aberrantly expressed lncRNAs and mRNAs in vocal cord leukoplakia and adjacent non-neoplastic tissues. Long non-coding RNAs (lncRNAs) play an important role in tumorigenesis. Vocal cord leukoplakia is a precancerous lesion in otolaryngological practice. Till now, the expression patterns and functions of lncRNAs in vocal cord leukoplakia have not been well understood.

Genes Activated in Metastasis Also Drive Initial Stages of Tumor Growth

In spite of the difference between the cell functions responsible for giving rise to a tumor and for the metastasis of this same tumor, studies at the Institute for Research in Biomedicine (IRB Barcelona) using the fly Drosophila melanogaster reveal that some genes can drive both phenomena.

The researchers have demonstrated that genes activated during metastasis are also able to initiate primary tumor development, and they explain the molecular mechanism involved. The study findings were published in PloS Genetics.