Recent cardiovascular outcomes trials for type 2 diabetes drugs have raised ethical concerns as they have left patients in the control groups exposed to high HbA1c levels for long periods of time, two former pharmaceutical company employees charge. The study has published online in the Journal of Clinical Investigation.
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Hypertension complications of pregnancies are associated with adverse effects such as eclampsia, stroke, renal and hepatic dysfunction, foetal growth restriction and stillbirth. Recognition, monitoring and treatment are thus key to reduce severe complications and mortality
Prospects for inhibiting the most dangerous symptoms of allergic reactions may be brighter with the publication of a new study that identifies a possible target for drug therapies.The study published in the Journal of Allergy and Clinical Immunology found that several proteins can interact in blood vessels to intensify the respiratory and circulatory symptoms of a severe allergic reaction known as anaphylaxis.
A new study examines a new imaging technique, scientists can now see into and study this complex fluid-filled matrix. Between the brain's neurons and glial cells is a critical but understudied structure that's been called neuroscience's final frontier: the extracellular space. The study is published in the journal Cell.
Colorectal cancer is one of the most common forms of cancer in Denmark and the third most frequent worldwide. Every year, approximately 5,000 Danes diagnosed with colorectal cancer, which could have many causes. Present study shows that presence of nitrate in drinking water might be one of them.
A global study of water and sanitation coverage has found that community access to sanitation facilities exceeding 80% reduces rates of trachoma, a blinding eye disease caused by repeated infection with Chlamydia trachomatis. The risk was lower even for people in the community without household access to sanitation.
Women in treatment for eating disorders need more nuanced information about reproductive health, and more thought needs to be given to how and why fertility information is delivered, according to a study published in Sociology of Health and Illness. Those with eating disorders (EDs) should have more input into their treatment "and" how medical information is communicated, the study suggests.
A German physician described the main chemical compounds responsible for the "rotting flesh" smell – a mix putrescine and cadaverine. But how do humans actually sense this terrifying smell? A new study, published in PLOS Computational Biology, has now uncovered the biochemical details. Bizarrely, the findings may be able to help treat major mood disorders such as depression.
This study compared an addition of dexmedetomidine prolonged the duration of analgesia as well as to compare the two techniques. The primary objective was to assess whether addition of dexmedetomidine to bupivacaine prolonged the duration of analgesia. The secondary objective was to compare between scalp nerve block and scalp infiltration as techniques for pain relief. Scalp infiltration and scalp block are being used to manage postcraniotomy pain. Dexmedetomidine has been successfully used as an adjuvant in regional anesthesia.
In this study, researchers examined the three-dimensional, molecular structure of the healthy human huntingtin protein with the help of cryo-electron microscopy. This now enables its functional analysis. An improved understanding of the structure and the function of the huntingtin protein could contribute to the development of new treatment methods in the future.
Researchers at the New York Genome Center (NYGC) and New York University (NYU) have taken steps to facilitate broad access to single-cell sequencing by developing a 3D-printed, portable and low-cost microfluidic controller. To demonstrate the utility of the instrument in clinical environments, the researchers deployed the device to study synovial tissue from patients with rheumatoid arthritis (RA) at the Hospital for Special Surgery (HSS).
A study of patients with obstructive sleep apnea (OSA) suggests that non-adherence to continuous positive airway pressure (CPAP) therapy is significantly associated with increased 30-day hospital readmissions. The study results are published in the Journal of Clinical Sleep Medicine.