All news from Anaesthesiology

New Insight into the Origin of Schizophrenia

Schizophrenia may be related to neurodevelopment changes, including brain's inability to create the appropriate vascular system, according to new study led by researchers from the D'Or Institute for Research and Education, the University of Chile and the Federal University of Rio de Janeiro (UFRJ). The results broaden the understanding about the causes of this severe and disabling disorder.

MCF-7 Breast Tumor Targeting and Imaging

In the present study, researchers radiolabeled FROP-1 peptide through practicing HYNIC as a chelating moiety (at the C-terminus) and Lys residue as a spacer in order to develop a 99mTc-HYNIC-(tricine-EDDA)-Lys-FROP for the targeting of the MCF-7 breast cancer cells.

Plenty of Metabolites produced by Antibiotic-Producing Bacterium

The bacterium Streptomyces chartreusis is an antibiotic-producing bacterium that releases more metabolites into the surrounding medium than scientists assumed based on the analysis of the genome. Many of the substances are likely released to mediate interactions with its environment. They might also include molecules that are of interest as potential pharmaceutical agents.

The researchers analyzed a broad spectrum of the bacterium's metabolic products under various culture conditions. The study is published in the journal Proceedings of the National Academy of Sciences.

Active and Passive Smoke Exposure in Urban Adolescents

Many adolescents are exposed to tobacco smoke, from either active smoking (CS) or secondhand smoke (SHS) exposure. Tobacco-specific biomarkers of exposure include cotinine (detects use in past 2–4 days) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL; detects use for a month or longer).

NNAL is expected to detect more intermittent tobacco exposure. Researchers compared NNAL and cotinine as biomarkers of exposure to tobacco in urban adolescents and determined the optimal NNAL cutoff point to distinguish CS from SHS exposure.