Schizophrenia may be related to neurodevelopment changes, including brain's inability to create the appropriate vascular system, according to new study led by researchers from the D'Or Institute for Research and Education, the University of Chile and the Federal University of Rio de Janeiro (UFRJ). The results broaden the understanding about the causes of this severe and disabling disorder.
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The passage of critical mine health and safety legislation in the late 1960s, along with advances in technology and safety practices, helped to decrease the prevalence of lung diseases for miners. But starting in the mid-1990s, there was a significant documented increase in lung diseases among coal workers, especially among younger workers.
In the present study, researchers radiolabeled FROP-1 peptide through practicing HYNIC as a chelating moiety (at the C-terminus) and Lys residue as a spacer in order to develop a 99mTc-HYNIC-(tricine-EDDA)-Lys-FROP for the targeting of the MCF-7 breast cancer cells.
Children with asthma have epigenetic DNA changes in certain cells of their immune system, according to a study published in The Lancet Respiratory Medicine. The study, led by researchers at Karolinska Institutet, can one day lead to improved diagnostics and therapeutic strategy for asthmatics.
Children with chronic kidney disease (CKD) may have lower intellectual functioning compared with the general population, with mild deficits across academic skills, executive function, and visual and verbal memory. The findings, which appear in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN), come from an analysis of studies published through 2016.
A total of 1.8 million young people between ten and 24 years of age are estimated to develop tuberculosis (TB) every year, with young adults aged 20 to 24 years at the greatest risk of developing infectious TB, according to research published in the European Respiratory Journal.
The bacterium Streptomyces chartreusis is an antibiotic-producing bacterium that releases more metabolites into the surrounding medium than scientists assumed based on the analysis of the genome. Many of the substances are likely released to mediate interactions with its environment. They might also include molecules that are of interest as potential pharmaceutical agents.
The researchers analyzed a broad spectrum of the bacterium's metabolic products under various culture conditions. The study is published in the journal Proceedings of the National Academy of Sciences.
Many adolescents are exposed to tobacco smoke, from either active smoking (CS) or secondhand smoke (SHS) exposure. Tobacco-specific biomarkers of exposure include cotinine (detects use in past 2–4 days) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL; detects use for a month or longer).
NNAL is expected to detect more intermittent tobacco exposure. Researchers compared NNAL and cotinine as biomarkers of exposure to tobacco in urban adolescents and determined the optimal NNAL cutoff point to distinguish CS from SHS exposure.
According to a study published in the March issue of The Journal of Urology, among patients who opt for active surveillance of small renal masses, growth rates are highly variable early on and do not reliably predict adverse outcomes.
Participants with higher levels of protein in their diet were less likely to have high levels of amyloid beta (Aβ) in their brain, reducing their risk of developing Alzheimer’s disease.
According to researchers in Taiwan, many hypertensive children with obstructive sleep apnea (OSA) who undergo adenotonsillectomy see a reduction in blood pressure (BP).