All news from Anaesthesiology

Sports Medicine Can Do Without Opioids

The problem of opioid addiction now affects us all. It was reported that a former National Football League quarterback Erik Kramer, tried to commit suicide after his 18-year-old son, a high school quarterback, died of a heroin overdose.

Cancer Immunotherapy: Researchers Develops New Technology

Johns Hopkins researchers have invented a new class of immunotherapeutic agents that are more effective at harnessing the power of the immune system to fight cancer.

Researchers approach results in significant inhibition of tumor growth, even against cancers which do not respond to existing immunotherapies used in the clinic. In collaboration with Insilico Medicine, a Baltimore-based leader in artificial intelligence for drug discovery, the team reports their results this week in Nature Communications.

Sickle Cell Disease: Feasibility of Bone Marrow Transplant

Among patients with severe hemoglobinopathies, greater total body irradiation followed by nonmyeloablative haploidentical allogeneic bone marrow transplant and posttransplant cyclophosphamide appeared associated with decreased graft failure, according to study results presented at the BMT Tandem Meetings.

Weight Loss Surgery Can Reduce The Risk Of Cancer

In this study, researchers estimated that the more weight gained, the higher the risk of cancer. Obesity is the biggest cause of cancer in the UK, after smoking. And with 2 in 3 UK adults either overweight or obese. But while it sounds logical that losing weight would reduce the risk. Most of this evidence comes from studies that have used body mass index (BMI) as a measure of body fat.

Leukaemia: Transcription Factor STAT5 was Targeted for Cure

Acute myeloid leukaemia is the most common type of acute cancer of the blood and bone marrow in adults. AML progresses quickly and only 26% of the patients survive longer than five years as resistance against established treatments develops.

The most common molecular cause is FLT3 mutations, which result in hyper-activation of STAT5. A research consortium now reports on an early preclinical effort targeting STAT5 that integrates well with existing therapies.

Study Finds Source of Toxic Green Algae Blooms

In St. Lucie Estuary, Florida, a massive amount of toxic green slime found that covered parts of the 7-mile-long inlet linked to a coastal river system.  Microcystis aeruginosa – a freshwater blue-green alga that can produce toxins – wreaked havoc on this important ecosystem prompting researchers from Florida Atlantic University's Harbor Branch Oceanographic Institute (HBOIto get to the root of the problem. Results of the study, which uncovered a major source of nutrients driving the harmful algal blooms, stink.

Glaucoma: New Directions in its Understanding and Prevention

Two distinctive handfuls of short molecules that regulate gene expression have been found in the eye fluid of patients with two distinct types of vision degenerating glaucoma.

These differentially expressed microRNAs point the way toward finding more genes associated with glaucoma, more clues about how these glaucoma types each go about damaging our optic nerve and potential new points of intervention, the scientists say.