New compounds targeting epigenetics have shown remarkable early activity in patients with lymphoma, according to data presented at the TAT (Targeted Anticancer Therapies) International Congress 2018 in Paris, France. ESMO's phase-I oncology meeting featured early clinical studies with BET inhibitors and EZH2 inhibitors.
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A new study, published in Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, reveals that people with major depressive disorder (MDD) feel more negative emotion when remembering painful experiences than people without the disorde
Human pluripotent stem cells (hPSCs) can infinitely self-renew and develop into all major cell types in the body, making them important for organ repair and replacement. But culturing them in large quantities can be expensive. Now researchers have developed a more cost-effective culture by using a new combination of chemical compounds.
The researchers aimed to derive a methodology to combine multiple functional imaging techniques to identify high-risk tumour subregions in NSCLC patients treated with (chemo)radiotherapy. Therefore, we developed a data-driven clustering approach to correlate the subregions to patient prognosis using FDG PET/CT to quantify metabolic activity, HX4 PET/CT to visualize hypoxia, and dynamic contract-enhanced CT (DCE-CT) to assess tumor vasculature.
A new study published in The New England Journal of Medicine (NEJM) suggest that common practice of quintupling the dose of inhaled glucocorticoids at the first sign of worsening asthma does not prevent exacerbations in children.
In this study, the human heart cells can divide and multiply, allowing the heart to grow and develop. The problem is that, right after birth, cardiomyocytes their ability to divide. The same is true for many other human cells, including those of the brain, spinal cord, and pancreas. The study has published in the journal Cell.
Nearly 90% of participants in an open-label study of a vaginal ring infused with a drug to prevent HIV are using the monthly ring at least some of the time, according to an interim analysis of study data. In addition, the rate of HIV infection among participants in the open-label study, which has no placebo arm for comparison, is half of what might be expected in the absence of the ring, according to mathematical modeling.
A new optical imaging system uses red and near-infrared light to identify breast cancer patients who will respond to chemotherapy, possibly as early as two weeks after beginning treatment, according to a study published in the journal Radiology. The non-invasive system tracks blood flow dynamics during a simple breath hold to predict patient responses.
New research reveals details of the mechanism by which the bacterium Wolbachia blocks viruses in mosquito cells, suggesting that it reduces viral replication inside cells and that rapid degradation of viral RNA is involved. Professor Scott O'Neill, Program Director of the World Mosquito Program, led by Australia's Monash University, and colleagues report their findings in PLOS Pathogens.
Diclofenac patches and piroxicam appear to be the most effective topical nonsteroidal anti-inflammatory drug (NSAID) for osteoarthritis (OA), according to a systematic review published in the British Journal of Sports Medicine.