All news from Anaesthesiology

cGVHD after Bone Marrow Transplant, Mechanism Uncovered

MicroRNA-17-92 is required for the T-cell and B-cell pathogenicity that drives chronic graft-versus-host disease (cGVHD) after allogeneic bone marrow transplant (BMT), report investigators.

Data from cGVHD mouse models showed that, by determining T-cell and B-cell differentiation and function, miR-17-92 is responsible for cGVHD development. Inhibiting miR-17 is a potential therapeutic strategy for preventing cGVHD in BMT patients.

Use Of Nasotracheal Intubation During General Anesthesia

A study examines tracheal collapse may have an increased anesthetic risk due to airway obstruction during induction and recovery. To our knowledge, there are no anesthetic descriptions of these patients, despite a reported 5.6% incidence and 77% mortality rate. Two Shetland ponies with tracheal collapse, a 12-year-old mal, and a 27-year-old female were referred for right eye enucleation due to a perforating corneal ulcer and severe recurrent uveitis, respectively.