Researchers have found that melanomas can be divided into four distinct subtypes according to their stages of differentiation. Cell subtypes that de-differentiated -; meaning that they reverted back to a less-mature cell, showed sensitivity to a type of self-inflicted cell death called ferroptosis. Melanoma, a relatively rare but deadly skin cancer, has been shown to switch differentiation states that is, to regress to an earlier stage of development, which can lead it to become resistant to treatment.
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Over the past decade, how patients receive their care in clinics has been transforming, from traditional primary care to patient-centered medical homes, focusing on team-based, coordinated, and whole-person care.
Researchers hypothesized that the CD-RISC-2-NP would demonstrate (1) acceptable internal consistency, (2) good test-retest reliability, and (3) construct validity via moderate negative correlations (i.e., rs ~ − 0.30) with measures of anxiety and depression.
They further hypothesized that the Nepali versions of CD-RISC-2 and CD-RISC-10 would (1) strongly correlate with each other, and (2) negatively correlate with the measure of pain intensity. Finally, we evaluated the standard error of measurement (SEM), minimum detectable change (MDC), and limits of agreement of both scales.
Camilla Andersson, a radiology nurse, demonstrated in a recent dissertation at Uppsala University that improved information before undergoing PET/CT scanning can improve patients' experience of care
Researchers demonstrates that transforming growth factor-beta 1(TGF-b1), a chemical cue released from immune cells, is a dominant activator of cardiac fibroblasts, which promotes scar tissue formation. They report that supporting cells in the heart, known as fibroblasts, are selectively activated by factors present in heart disease. The study was published in Experimental Biology and Medicine.
Infections caused by multidrug-resistant bacteria, which has been common in patients with cirrhosis, are associated with a significant elevation in risk for in-hospital mortality, results from a global study show.
Researchers create new assessment tools that build on the Glasgow Coma Scale in order to provide greater information on injury severity and prognosis in patients with traumatic brain injury (TBI) while still offering the simplicity of use. These tools are described and evaluated in two companion papers published in the Journal of Neurosurgery.
Is arthritis pain getting in the way of your fitness plans? That need not be the case. In fact, physical activity can be vital to your continued mobility, a new study suggests.
If you have osteoarthritis, participating in joint-friendly physical activity can improve your arthritis pain, function, mood, and quality of life.
Researchers from Mount Sinai and Sema4, a health information company and Mount Sinai venture, have discovered that giving metastatic bladder cancer patients simultaneous chemotherapy and immunotherapy is safe and that patients whose tumors have certain genetic mutations may respond particularly well to this combination approach, according to the results of a clinical trial published in European Urology.
For 93-year-old Joseph Brown, the clearest sign of aging was his inability one day to remember he had to have his pants unzipped to pull them on. For 95-year-old Caroline Mayer, it was decided at age 80 to put away her skis, after two hip replacements.
Researchers from the Washington University School of Medicine have shown, in mice, that the virus infects a rare type of intestinal cell called a tuft cell. The findings, published in the journal Science suggest that targeting tuft cells with a vaccine or a drug may be a viable strategy for preventing or treating norovirus infections.
Researchers investigated the effect of providing video information on anxiety and satisfaction in patients about to undergo spinal anesthesia. Providing sufficient information during a pre-anesthesia consultation can increase patient understanding and decrease anxiety related to spinal anesthesia. Surgical patients usually present with preoperative anxiety, which seems to begin as soon as the surgical procedure is planned. Anesthesia-related fear and its implications are an important source of this anxiety.