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A Qualitative Study on Non-Cephalic Births in Rural Sarlahi District, Nepal

In low-resource settings, a significant proportion of fetal, neonatal, and maternal deaths can be attributed to intrapartum-related complications. Certain risk factors, such as non-cephalic presentation, have a particularly high risk of complications.

This qualitative study describes experiences around non-cephalic births and highlights existing perceptions and care-seeking behavior specific to the non-cephalic presentation in rural Sarlahi District, Nepal.

Pectoralis Major Flap For The Treatment Of Pharyngocutaneous Fistulas

Researchers examined that the pectoralis major flap is a reconstructive option to consider in the treatment of pharyngocutaneous fistula after a total laryngectomy. There are not large studies assessing variables related to pharyngocutaneous fistula recurrence after removal of the larynx. Our objectives were to review the results obtained with this type of treatment when pharyngocutaneous fistula appears in laryngectomized patients and to evaluate variables related to the results.

Protein Structure Is Revealed By Using High-Resolution Cryo-Electron Microscopy

Researchers team have determined for the first time the high-resolution structure of a complex (R2TP) involved in key processes for cell survival and diseases such as cancer. This achievement has been made possible by using high-resolution cryo-electron microscopy, a technique brought to the CNIO thanks to Óscar Llorca, director of the Structural Biology Programme. The study was published in Nature Communications.

Protein Aggregates Protect Rather Than Harm Neurons

Researchers examine by an understanding of the complex and fatal neurodegenerative disease amyotrophic lateral sclerosis(ALS), also known as Lou Gehrig's disease. Autopsy studies of ALS patients often reveal the accumulation of large, fibrous aggregates of a protein called SOD1 in disease-affected motor neurons. Researchers have hypothesized that these fibrils are what kill neurons and cause ALS in some people. They found evidence that these large SOD1 fibrils protect rather than harm neurons. The study was published in the Proceedings of the National Academy of Sciences.

Anatomy Of Olivocochlear Efferents in Humans About Clinical Relevance

Olivocochlear efferents allow the central auditory system to adjust the functioning of the inner ear during active and passive listening. While many aspects of efferent anatomy, physiology and function are well established, others remain controversial. The auditory nervous system is continuously sensing and interpreting the sounds around us. Our ears operate as the sound detectors, transducing acoustic pressure into auditory nerve action potentials, and coding the characteristics of sounds appropriately for further processing by the central auditory system.