Researchers from the University of Minnesota Medical School and Minneapolis Medical Research Foundation at Hennepin Healthcare is developing vaccines against heroin and prescription opioids, such as oxycodone and fentanyl. These vaccines function by using the immune system to produce molecules (antibodies) that target, bind, and prevent opioids from reaching the brain (the site of drug action). Heroin and prescription opioid abuse and fatal overdoses are a public health emergency in the United States. Vaccines offer a potential new strategy to treat opioid abuse and prevent fatal opioid overdoses.
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A new study, by the Marie Curie Palliative Care Research Centre at Cardiff University Cardiff University, looking at the personal perceptions and experiences of patients, families and healthcare professionals, has highlighted the need for further evidence to improve symptom management in end of life care.
Exposure to moderate to high caffeine levels while in the womb is linked to excess weight gain in early childhood suggests a large observational study published in the online journal BMJ Open
A New Study examines that drinking does not help matters, with drunk concertgoers moving closer to loudspeakers. High-decibel music blasting at big concert venues is a known cause of short-term hearing loss. The study of 51 young attendees at an outdoor music festival in the Netherlands found that "when participants consumed more alcohol, they exhibited more dangerous behaviour" tied to hearing loss. The study was published in JAMA Otolaryngology-Head & Neck Surgery.
French researchers uncovered new chromosomal mutations and illustrated their role in the evolution of resistance of Escherichia coli (E. coli) to broad-spectrum antibiotic fosfomycin, a new study presented at the 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) reports.
Research is conducted to provide a better understanding of the processes underlying cell-to-cell differences within Glioblastoma (GBM) tumours – a crucial finding because these differences contribute to therapy resistance
Over a thousand people die from malaria every day. The disease is caused by a single-cell parasite (protozoan) that is transmitted by mosquitoes. The malaria parasite is highly dependent on a unique protein for infecting new mosquitoes. This protein could be a target for the development of new drugsAnti-malaria efforts currently focus on effective diagnostics, mosquito nets, insecticides and drugs. Additionally, a strong effort is being made at Radboud university medical centre and other institutes to develop a vaccine.
General surgery residents are more likely to finish their training if they have a clear picture of the stress involved before they start, researchers report in an article published online in JAMA Surgery.
A new study, published in the journal Arthritis Research and Therapy, reports that increased levels of interleukin-37 can be used as an efficient disease activity marker in patients with adult-onset Still’s disease.
A study compared the effects of a traditional warm-up with two post-activation potentiations (PAP) warm-up strategies on the repeated sprint ability (RSA) of soccer players from national (NL) and regional (RL) competitive levels. Sixteen young players were recruited to complete a traditional warm-up, a PAP warm-up incorporating squats with a load (~60% 1RM) that allowed a high speed (1 m/s) of movement and a high number of repetitions (PAP-1), and a PAP warm-up with a load (~90% 1RM) that allowed a moderate speed (0.5 m/s) of movement and a reduced number of repetitions (PAP-0.5).
Delirium is a sudden change in mental status that often occurs when older adults are in the hospital or after they have surgery. More than 20% of older adults may experience delirium. Prolonged delirium could have a lasting impact on health and well-being.