All news from Anaesthesiology

To Prevent Cancer, Protein Goes Against the NF-?B Family

Researchers have made the surprise discovery that the 'odd one out' in a family of proteins known to drive cancer development is instead critical for preventing stomach cancers.  The research team showed switching off a gene called NF-κB1 caused the spontaneous development of stomach cancers, driven by chronic inflammation. The study also revealed that immunotherapy may prove to be a significant tool for treating stomach cancers that are driven by runaway inflammation, warranting further investigation. The study was published in the journal Immunity.

Evaluation Of The Prevalence, Risk Factors, And Prognosis Of fungal Infections In adults

A study evaluated the prevalence, risk factors, and prognosis of fungal infections in adults on ECMO. Patients on extracorporeal membrane oxygenation (ECMO) are often among the most severely ill in the intensive care unit. They are often receiving broad-spectrum antibiotics; they have multiple entry points for pathogens, and their immune system is impaired by blood circuit interaction. These factors are thought to predispose them to fungal infections. 

Non-Nucleotide Reverse Transcriptase Inhibitor Is Effective in Treating Adults Infected With HIV

According to a study, researchers estimated that Doravirine, an investigational non-nucleoside reverse transcriptase inhibitor (NNRTI), is as effective as ritonavir-boosted darunavir, a protease inhibitor, in treatment-naive adults infected with HIV-1. "Doravirine may be an option for people with HIV who are treatment naive. "Doravirine addresses the disadvantages of current NNRTIs that caused them to be demoted as preferred or recommended treatment options.