All news from Anaesthesiology

To Compare Lymphocyte Subset Expression Of PD-1 Between Patients With Sepsis

A study is to determine if serum concentrations correlated with cell surface expression. Sepsis remains a major cause of mortality in critical care, for which specific treatments are lacking. The dysregulated response to infection seen in sepsis includes features of lymphocyte dysfunction and exhaustion. Monoclonal antibodies targeting checkpoint molecules, such as programmed-death one protein (PD-1) and its ligand PD-L1, have shown success in stimulating the immune response in patients with cancer, and are being considered for future sepsis trials.

Restoring Leaky Blood Vessels Could Lead to Tuberculosis Treatment

Researchers from the Duke University have found that an FDA-approved drug developed to treat cancer helps fight tuberculosis. The drug is an MMP inhibitor designed to increase the structural integrity of blood vessels in tumors so that other drugs can reach inside them. It performs the same function in the granulomas associated with tuberculosis so that antibiotics can reach the bacteria sheltering within.

Scientists Solved 20-year-old Mystery of Effective Malaria Vaccine

There is a revelation for the first time solving a long-standing mystery, a protein displayed on the surface of malaria parasites called “TRAP” is a high-priority vaccine target, but how it interacts with human host cells has remained a puzzle.

Scientists from the Wellcome Sanger Institute have identified a receptor protein on the surface of human cells that the TRAP protein interacts with as it navigates through the body. The results, published in PNAS could help improve the development of an effective malaria vaccine.

Lower Limb Orthopedic Surgery Uses Regional Anesthesia

A study estimates that regional anaesthesia is safe and effective for lower limb orthopaedic surgery in a patient with renal tubular acidosis and hypokalemia. Renal tubular acidosis (RTA) with hypokalemia may precipitate acute respiratory failure and potentially fatal arrhythmias like ventricular fibrillation. Though there are random reports of respiratory failure needing mechanical ventilation and sudden death in patients with RTA and hypokalemia, the anaesthetic management of these patients has not been elucidated