A study is to determine if serum concentrations correlated with cell surface expression. Sepsis remains a major cause of mortality in critical care, for which specific treatments are lacking. The dysregulated response to infection seen in sepsis includes features of lymphocyte dysfunction and exhaustion. Monoclonal antibodies targeting checkpoint molecules, such as programmed-death one protein (PD-1) and its ligand PD-L1, have shown success in stimulating the immune response in patients with cancer, and are being considered for future sepsis trials.
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Sarilumab monotherapy showed greater improvements compared with adalimumab monotherapy among patients with rheumatoid arthritis when measured using erythrocyte sedimentation rate, but the two treatments were generally similar terms of participants who achieved the ACR50 response rate, a new study published in the Annals of the Rheumatic Diseases.
US senators have put on hold hearing on the nomination of Rear Admiral Ronny L. Jackson, to be secretary of the US Department of Veterans Affairs and have issued a bipartisan call for documentation and communication with federal agencies regarding troubling concerns about past incidents.
Researchers from the Duke University have found that an FDA-approved drug developed to treat cancer helps fight tuberculosis. The drug is an MMP inhibitor designed to increase the structural integrity of blood vessels in tumors so that other drugs can reach inside them. It performs the same function in the granulomas associated with tuberculosis so that antibiotics can reach the bacteria sheltering within.
According to a prospective study, researchers examine that most of the men with symptomatic Zika Virus (ZIKV) infections had the ZIKV genetic footprint in their semen for at least 30 days after symptom onset, but only 4% had an infectious virus. The study was published in the New England Journal of Medicine.
Even the briefest exposure to airborne fine particulate matter PM2.5, pollution-causing particles is associated with the development of acute lower respiratory infection (ALRI) in young children, according to a study published in the journal American Journal of Respiratory and Critical Care Medicine.
Scientists have just made a surprising discovery involving fat and special immune cells that live within which it turns out that 'gd T cells' are the key cogs in the biological wheel that regulates our body heat and protects us against cold shock.
A new study suggests that cavity prevention programs with a combination of prevention strategies may be more effective than one alone for reducing tooth decay. The study was published in the journal BMC Oral Health.
There is a revelation for the first time solving a long-standing mystery, a protein displayed on the surface of malaria parasites called “TRAP” is a high-priority vaccine target, but how it interacts with human host cells has remained a puzzle.
Scientists from the Wellcome Sanger Institute have identified a receptor protein on the surface of human cells that the TRAP protein interacts with as it navigates through the body. The results, published in PNAS could help improve the development of an effective malaria vaccine.
A study estimates that regional anaesthesia is safe and effective for lower limb orthopaedic surgery in a patient with renal tubular acidosis and hypokalemia. Renal tubular acidosis (RTA) with hypokalemia may precipitate acute respiratory failure and potentially fatal arrhythmias like ventricular fibrillation. Though there are random reports of respiratory failure needing mechanical ventilation and sudden death in patients with RTA and hypokalemia, the anaesthetic management of these patients has not been elucidated