The present study demonstrated the most robust 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) changes in the left posterior cingulate cortex (PCC)/precuneus in amnestic mild cognitive impairment (aMCI) converters relative to aMCI non-converters at baseline
A study developed a new type of 'double-bridged peptide' that can be tailored to bind tightly to disease targets of interest. The peptides' highly efficient binding, combined with their small size and high stability make them ideal for drug therapies. Peptides are short chains of amino acids that can bind to proteins and change their function. They show a high binding affinity, low toxicity, and are easy to synthesize, all of which makes peptides ideal for use in drug development, and many naturally occurring peptides such as insulin, oxytocin, somatostatin and the antibiotics vancomycin or polymyxin B, are already successfully used like that.
A team of researchers have identified factors that may increase the risk of a drug overdose in adolescents and young adults. They describe finding that more than a quarter of those seeking treatment at Addiction Recovery Management Service, an MGH-based outpatient substance-use-disorder treatment program for youth ages 14 to 26, had a history of at least one overdose. Factors associated with increased overdose risk were disorders involving the use of alcohol, cocaine or amphetamines and histories of depression, anxiety or eating disorders. The study was published online in the Journal of Clinical Psychiatry.
Inhaled medications play an important role in treating chronic obstructive pulmonary disease, or COPD, and it is imperative that the inhaler device be used properly to effectively treat the disease.
However, in a recently released study in the Journal of the COPD Foundation, researchers found that healthcare providers and patients prioritize medication over the device when selecting treatments, showing limited concerns about proper device use.
According to campaigners accusing the global community of again failing the Caribbean nation. Haitians battling cholera blamed on United Nations peacekeepers are getting little support with only two percent of promised funds materializing, Haiti was free of cholera until 2010 when peacekeepers helping after a devastating earthquake that killed more than 250,000 people accidentally dumped infected sewage into a river.
According to a new study, researchers examined the effects of night-time light exposure on internal body clock processes. This is important for helping those who have a poor quality sleep, such as shift workers, and could help improve treatments for depression. The study was published in The Journal of Physiology.
Patients undergoing physical rehabilitation at Rush for paralyzing injuries are being aided by a robotic suit designed to help raise people to full height and walk.Rush is the only medical centre in Chicago and one of only 98 facilities in the world offering the EksoGT robotic exoskeleton device for clinical therapy for both inpatients and outpatients.
Primary care management of obstructive sleep apnea (OSA) is as effective and more cost-effective than in-laboratory diagnosis, according to a study published online April 17 in the American Journal of Respiratory and Critical Care Medicine.
Neuroscientists have developed an MRI sensor that lets them monitor neuron activity deep within the brain by tracking calcium ions. This type of sensing could allow researchers to link specific brain functions to their pattern of neuron activity.
Cocaine and other drugs of abuse hijack the natural reward circuits in the brain. In part, that is why it is so hard to quit using these substances. Moreover, relapse rates hover between 40 and 60%, similar to rates for other chronic conditions like hypertension and Type 1 diabetes.
In a rare series of moves, the Dutch authorities have been investigating whether doctors might have committed crimes in five euthanasia cases, including the deaths of two women with advanced Alzheimer's disease.
Royal Philips, a global leader in health technology, would showcase its integrated radiation oncology solutions in the exhibition at the European Society for Radiation Oncology’s (ESTRO) 37th Annual Meeting in Barcelona, Spain.