All news from Anaesthesiology

Aortic Valve Endocarditis: A standardized Approach For Treatment

Guidelines support the use of both homografts and stentless bioprostheses in aortic valve endocarditis with paravalvular abscess formation. The choice of prosthesis depends on patient characteristics, technical considerations, and surgeon preferences.

In this illustrated series of sixteen patients with aortic valve endocarditis and complicating paravalvular abscess formation, researchers show that the use of stentless bioprostheses provides a more standardized surgical procedure that consists of thorough debridement, root replacement with reimplantation of the coronary arteries, and treatment of accompanying pathologies.

CardiAmp Therapy Shown Improvements In Heart Function

In Previous clinical studies of CardiAmp Therapy have been promising and have shown improvements in patients' quality of life and heart function. The CardiAMP investigational therapy is a minimally invasive treatment for ischemic heart failure which occurs after a heart attack. The therapy includes a pre-procedure screening test. A small bone marrow sample is taken and screened to identify patients with a higher likelihood of benefitting from the treatment.

Neurons Decides Whether to Make or Break New Connections

As the brain grows and develops, nerve cells must make connections between one another in order to function properly. Brain cells are tightly packed together, so each cell might touch hundreds or thousands of other cells, and yet those cells only make stable and strong connections with a fraction of those neighboring cells

A Key Element Of Brain Physiology Is Able To Function In Hostile Environment

During a stroke or an epileptic seizure, neurons in affected parts of the brain fire at an abnormally rapid rate. Using a powerful microscopy method called cryo-EM, biologists at Cold Spring Harbor Laboratory (CSHL) have discovered how one key element of brain physiology, a docking port for excitatory neurotransmitters called the NMDA receptor, is able to function in this hostile environment. One byproduct of this condition is that the pH of the brain drops markedly, rendering the local environment inhospitably acidic. 

Transgender People Access To Mental Health Treatment

The researcher has found that transgender people who are denied access to mental health treatment experience a higher risk of substance abuse and attempted suicide. They hold critical implications for service access and delivery policies that protect transgender help-seekers in the health care system. An estimated 1.8 million Americans identify as transgender. The study was published online in Administration and Policy in Mental Health and Mental Health Services Research,

Plazomicin Recommended for cUTI but Not BSI

The US Food and Drug Administration's (FDA's) Antimicrobial Drugs Advisory Committee recommended plazomicin (Achaogen Inc) for complicated urinary tract infections (cUTIs) but not for bloodstream infections (BSIs) in adults with limited or no treatment options.

New Protein That Plays A Major Role In Genetic Stability Of Our Cells

A study examined that researchers have identified a new protein that is important to the genetic stability of our cells. It may be significant for the development of new drugs against genetically determined diseases like cancer, sterility, and premature aging. All of our cells contain genetic material, DNA, which controls the activity of the cells. If the genetic material is damaged, cancer cells may develop. Therefore, many proteins and enzymes are responsible for stabilizing and protecting our DNA against permanent damage and mutations.

Erythropoiesis: Different effects of G-CSF and EPO

The present study further investigated the differences between G-CSF and EPO on erythropoiesis. After mice had been treated with G-CSF and EPO, the erythropoiesis status in the BM and spleen were compared using flow cytometry.

The stimulation of early erythroid progenitor subsets and temporal regulation of erythroid progenitor mobilization were characterized. The mechanism of G-CSF promotion of erythropoiesis was also discussed.