All news from Anaesthesiology

Mechanism Of The Two-Component ?-Helical Pore-Forming Toxin

Researchers have unraveled the mechanism of action for one of these toxins. The findings could help combat associated diseases and advance crop protection. Pore-forming toxins are common bacterial poisons. They attack organisms by introducing holes in cell membranes. YaxAB was shown to be cytotoxic and likely involved in pathogenesis, though the molecular basis for its two-component lytic mechanism remains elusive. Here, they present crystal structures of YaxA and YaxB, together with a cryo-electron microscopy map of the YaxAB complex. 

An Abnormal Heart Rhythm Can Lead To Higher Risk Of Stroke

A study determined that researchers have found that people whose heart rhythm returns to normal continue to be at high risk of stroke and should continue to be treated. Patients with an abnormal heart rhythm that can leave them at a higher risk of suffering from stroke still need treatment even after their heart rhythm seems to have returned to normal. The study was published in The BMJ

New Strategy To Tolerate the Infection Without Eliminating Pathogen

The prospective study has recently been challenged as scientists have taken a lesson from plant biologists about an ancient strategy involving the ability to "tolerate" rather than "resist" infection to maintain health. This concept referred to as "disease tolerance", provides an opportunity to develop new strategies that mitigate the consequences of infection

A Molecular Switch With Two Compounds Reacts In The Same Solution

Researchers have found a molecular switch such that two compounds that would readily react with each other can be in the same solution, separated by a very thin membrane and kept from reacting with each other until a molecular switch is thrown. They showed the movement of a single chemical bond can compromise a membrane made up of more than 500 chemical bonds. Their system uses light as a switch to create a reversible, on-demand molecular control mechanism. The study was published in Nature Chemistry.

New Mechanism Involved In Depression

A study developed a new mechanism, which is involved in depression and a way to target it with a drug as effective as classical antidepressants provide new understanding of this illness and could pave the way for treatments with fewer side effects. The study was published in Nature Medicine