All news from Anaesthesiology

Human Herpes Virus 8 in HIV-1 Infected Individuals

While it is well established that the tissue presence of HHV8 in combination with immunosuppression leads to the development of clinical KS, there are limited data on the dynamics of circulating HHV8 in HIV infected individuals receiving cytoreductive chemotherapies for various malignancies, or the impact of anti-tumor therapies on HHV8 viremia.

Furthermore, it is possible that circulating HHV8 may be associated with increased immune activation and exhaustion, but studies focusing on the associations between HHV8 viremia, CD4+ T cell counts, and lymphocyte phenotypes in the setting of HIV and malignancy are lacking. To address these issues, we examined the associations between different systemic cancer chemotherapies for KS and other malignancies with T cell counts and phenotype, circulating HHV8 DNA, HIV infection and clinical KS.

Safety And Effectiveness Of A Drug Given In The Prehospital Setting

The acute behavioral disturbance is a common problem for emergency medical services. They aimed to investigate the safety and effectiveness of droperidol compared to midazolam in the prehospital setting. Paramedics are using a new drug to quickly calm violent patients and they have the data to prove it works. Researchers found the sedative, droperidol, was a safer and faster option for paramedics to use compared with the internationally accepted, midazolam. The study was published in the Journal of Prehospital Emergency Care.

An Autoimmune Disorder Leads To Skin Cancer

According to a study, the researcher examined that overactive immune response, which can occur with viral infections, could result in sudden hair graying. The research revealed that a molecule involved in hair pigmentation also controls certain immune system genes. The study explains that skin might lead to rapid graying, but it may provide insights into the skin condition vitiligo, an autoimmune disorder in which the skin loses its color, and melanoma, a cancer of skin pigment cells. The study was published in PLoS Biology.

New Approach To Predict Success Of Cancer Therapy

Scientists at the Stanford University School of Medicine have invented a litmus test for the effectiveness of a newly devised cancer therapy. The molecule is a radioactive tracer that latches onto immune cells when they are activated—the status that immune cells, in particular, T cells, assume when they are poised to kill tumor cells

 

 

People Become Overweight/Obese Leads To Diabetes

According to a study, the researcher estimates that more than 27 million people in the United States living with type 2 diabetes. As the population ages and a growing percentage of people become overweight or obese, that number is expected to increase. A potential new approach for treating diabetes by protecting beta cells the cells in the pancreas that produce, store and release the hormone insulin. The study was published in Cell.