All news from Anaesthesiology

HIV Prevention: Risk-profiling can Benefit the Patients

That men who have sex with men run a greater risk of HIV than others has been known since the virus was discovered. However, a thesis from Karolinska Institutet now shows that it is a small sub-group of these men who account for the greater part of the risk increase. The results are important to preventive efforts against HIV in Sweden.

Chaperones Convert The Energy Into The Nonequilibrium Stabilization Of Native Proteins

Chaperones are specialized proteins in the cell that help other proteins to reach their functional 3D shapes, which correspond to the states preferred at thermodynamic equilibrium. But a new study by EPFL, UNIL and INSERM (France) scientists shows that chaperones can also maintain proteins in non-equilibrium states, potentially altering their fate. The study was published in Nature Chemical Biology.

Diseased Heart Muscle Cells Have Short Telomeres

Researchers say the finding could lead to new pathways for drug discovery. People with cardiomyopathy have abnormally short telomeres in the muscles that contract the heart. A telomere is a DNA sequence that serves as a protective cap on the ends of chromosomes.

A previous study showing that people with Duchenne muscular dystrophy, a genetic muscle-wasting disease, also have short telomeres in their heart muscle cells or cardiomyocytes. These patients often die at an early age from heart failure. The study was published in the Proceedings of the National Academy of Sciences.

Structure Of The Human Epithelial Sodium Channel By Cryo-EM

New research for the first time reveals the three-dimensional structure of a membrane channel that's critical in controlling blood pressure. The findings represent the first time the human epithelial sodium channel has been shown so precisely since it was first isolated and described through expression cloning more than two decades ago.

The breakthrough could lead to 'new and better treatments blood pressure medications. The study was published in the journal eLife.

Disease-Causing Mutation Found in French-Canadians

A team of Canadian scientists, including researchers at the Montreal Neurological Institute and Hospital (The Neuro), has discovered the first French-Canadian founder mutation gene linked to synucleinopathies, a group of neurodegenerative diseases that includes Parkinson's disease (PD), dementia with Lewy-bodies (DLB) and multiple system atrophy (MSA)

Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome A Circadian Clock

It turns out timing really is everything, at least when it comes to the diets of lab mice that have their circadian clocks disrupted. The study was published in Cell Metabolism. It is reporting that limiting the times when the animals eat can correct obesity and other metabolic problems that are normally seen in these mice, even when they're fed an unhealthy diet. The results suggest a previously unknown link between disruption of the clock and eating behavior.

Ethicon Demonstrates Life-Changing Obesity Treatment

Ethicon, part of Johnson & Johnson Medical Devices Companies (JJMD), demonstrates its commitment to improving access to life-changing obesity treatment and putting the most appropriate surgical tools in surgeons hands at the 23rd World Congress of the International Federation for the Surgery of Obesity and Metabolic Diseases (IFSO 2018).