All news from Anaesthesiology

Cells Alter tRNA Mechanism To Regulate Protein Synthesis

New research has uncovered the mechanism used by cells to optimize the production of proteins in stressful situations by altering tRNA abundance. The regulating mechanism may play a vital role in preventing the proliferation of tumors.

Researchers from the Universitat Autònoma de Barcelona, and the Medical Research Council Cambridge (UK), for the first time, describe the mechanism used by cells to optimize the production of proteins in stressful situations by altering tRNA abundance.

Need for HPV Vaccination to Reach Public Health Goal

Nearly 14 million additional adolescents (11-12 years of age) beyond those who will be vaccinated based on current rates will need to receive the human papillomavirus (HPV) vaccine between now and 2026 to reach the American Cancer Society's goal of an 80% vaccination rate by that year.

The figure comes from a new report from American Cancer Society investigators looking to guide HPV cancer control efforts in the wake of recent goal-setting. The report appears early online in Cancer.

Sedation Is Unnecessary For Colonoscopy

Deep sedation for routine colonoscopy is of marginal benefit, costs more and may negatively affect safety and quality compared with mild-to-moderate sedation with traditional sedatives. The increasing use of deep sedation for colonoscopy in North America is a trend that should be curtailed to reduce unnecessary spending associated with procedures, and needless intervention that may cause harm.

In many countries, a large proportion of colonoscopies are performed with little or no sedation. According to a national audit in the United Kingdom, 0.4% of colonoscopies were performed using propofol, a short-acting drug that induces a state of deep sedation, and 10.7% were performed without sedation.