The molecular mechanisms involved in myogenic differentiation are relatively well-known. Myogenic differentiation is regulated by the sequential activation of the basic helix-loop-helix myogenic regulatory transcription factors (MRFs), and biomechanical signals play an important role in the regulation of myogenesis. Astronauts go through many physiological changes during their time in spaceflight, including lower muscle mass and slower muscle development. Similar symptoms can occur in the muscles of people on Earth's surface, too. In fact, it could affect everyone to some extent later in life. The study was published in npj Microgravity.
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An operation that targets the nerves connected to the kidney has been found to significantly reduce blood pressure in patients with hypertension, according to a clinical-trial led in the UK by Queen Mary University of London and Barts Health NHS Trust
A single injection of androgen deprivation therapy (ADT) for men otherwise being managed with active surveillance for low-risk prostate cancer improves a number of short-term outcomes and may eradicate small malignancies, according to results from a novel phase 3 trial from France.
Scientists have shown that a small cluster of cells in the human embryo dictates the fate of other embryonic cells. The discovery of this developmental 'organizer' could advance research into any human diseases, and it suggests we have more in common with birds than meets the eye. The factors that shape the destiny of a cell, like that of a fully formed person, remain something of a mystery. The study was published in the journal Nature.
The Drug and Cosmetics Act governs transfusion services in India and mandates testing for Human Immunodeficiency virus (HIV), Hepatitis B virus (HBV), Hepatitis C virus (HCV), Syphilis and Malaria on all donor units.
Groundbreaking research shows that neurological health depends as much on signals sent by the body's large, leg muscles to the brain as it does on directives from the brain to the muscles
The researcher estimates that US Food and Drug Administration (FDA) advisory committee has voted overwhelmingly against approving a sublingual form of buprenorphine for the treatment of moderate-to-severe acute pain. The joint meeting of the Anesthetic and Analgesic Drug Products Advisory Committee and the Drug Safety and Risk Management Advisory Committee voted 18-1 against the approval of Buvaya, a spray form of buprenorphine an opioid that is primarily used for medication-assisted treatment.
A 5-year healthy lifestyle counseling program for adult men was linked with a reduced risk of developing cancers related to overweight, diet, and smoking over 25 years. As reported in the Journal of Internal Medicine, the intervention did not reduce the overall cancer risk in the very long term.
Scientists at UC San Francisco have developed a test to predict a woman's risk of preterm birth when she is between 15 and 20 weeks pregnant, which may enable doctors to treat them early and thereby prevent severe complications later in the pregnancy