All news from Anaesthesiology

Redesigned Enzymes Catalyze Assymetric Hydroamination Reactions

Researchers used a computational method to redesign aspartase and convert it to a catalyst for asymmetric hydroamination reactions. Their colleagues in China scaled up the production of this enzyme and managed to produce kilograms of very pure building blocks for pharmaceuticals and other bioactive compounds. They used a computational method to redesign aspartase and convert it to a catalyst for asymmetric hydroamination reactions. The study was published in Nature Chemical Biology.

High Blood Pressure Should Be Treated With Medication

According to a new study, researchers estimated one out of every three U.S. adults has high blood pressure that should be treated with medication, under guidelines recently adopted by the two leading heart health associations. The American College of Cardiology and American Heart Association redefined high blood pressure, based on new evidence supporting a lower threshold. The new study was published in JAMA Cardiology.

Mortality Data Made More Meaningful

Recording the causes of mortality and using that data to drive public health interventions like drug and vaccine procurement, running screening and awareness campaigns, and providing secondary and tertiary care under health insurance schemes can help public health achieve better outcomes.

Structural Basis For Gating Pore Current In Periodic Paralysis

Researchers found a rare genetic disorder in which people are suddenly overcome with profound muscle weakness is caused by a hole in a membrane protein that allows sodium ions to leak across cell membranes. A hole in a protein lets ions leaks into cells, thereby triggering the profound muscle weakness of hypokalemic periodic paralysis. The study was published in the journal Nature.

Lyme disease and its Prevalence in Southern Indiana

A new environmental monitoring project at Indiana University has found increased numbers of the ticks that carry Lyme disease in Southern Indiana. The organisms, deer ticks, are not yet confirmed to carry Lyme disease. However, IU researchers said the presence of a known disease vector — like a deer tick — is commonly followed by a rise in the illness caused by the bacteria it carries.

To determine If Green Space Associated With Schizophrenia Risk?

Schizophrenia risk has been linked to urbanization, but the underlying mechanism remains unknown. Green space is hypothesized to positively influence mental health and might mediate risk of schizophrenia by mitigating noise and particle pollution exposure, stress relief, or other unknown mechanisms. People who grew up without green spaces are 50% more likely to develop schizophrenia compared with those who grew up surrounded by greenery. The study was published in the journal Schizophrenia Research.