All news from Anaesthesiology

New Technology Developed to Manage Cancer Pain

As cancer patients become increasingly ill toward the end of their lives, their pain often intensifies and increases in frequency. This is distressing not only to the patient, but also to the patient's caregivers, often a spouse or partner. Effectively managing that pain with medications and other therapies is of utmost importance, but also difficult to accomplish for most lay caregivers.

Peptide Hormones Flatten Social Hierarchy And Synchronize Behaviours

A study showed Oxytocin's effects on human social behavior are not clear. Some studies reveal significant positive changes, yet others show none at all. In many animals, from rodents to non-human primates, it's a different story: Oxytocin has been proven to increase positive social behaviors and attention paid to others, and reduce negative social behaviors like threats and vigilance. The hormones flatten group hierarchy, resulting in dominant monkeys becoming more relaxed and subordinate monkeys becoming more confident. The study was published in Scientific Reports

Effectiveness of SHP2 Inhibitors Against Hard-to-Treat Cancers

A new anti-cancer drug may be effective against a wider range of cancers than previously thought. Using a mouse model and samples taken from cancer patients researchers has shown that a new class of drugs known as SHP2 inhibitors is also effective against aggressive, hard-to-treat tumors such as lung and pancreatic cancers. Clinical trials currently underway had previously excluded patients with these cancers.

Genome's Dark Matter: New Insights of Prostate Cancer

The dark matter of the human genome may shed light on how the hormone androgen impacts prostate cancer. Researchers at the University of Michigan Rogel Cancer Center identified a novel gene they named ARLNC1 that controls signals from the androgen receptor, a key player in prostate cancer. Knocking down this long non-coding RNA in mice led to cancer cell death, suggesting this may be a key target for future therapies. The study is published in Nature Genetics.

Diabetic Septic Foot: Hemostatic State Augmented with Platelet Indices

The study reports suggest that platelets with variable morphology could be associated with an increased risk of vascular complications in diabetes. Hyperglycemia, in turn, may contribute to endothelial dysfunction and vascular damage.

This condition exerts an increased platelet reactivity and promotes glycosylation of platelet proteins. This study was designed to evaluate the alteration in coagulation parameters and platelet indices and their relation to diabetic septic foot in Sudanese patients.