Researchers describe a new means of searching vast repositories of compounds produced by microbes. By analyzing the mass spectra of the compounds, they were able to identify known compounds within the repository and eliminate them from further analysis, focusing instead on the unknown variants that might potentially be better or more efficient antibiotics, anticancer drugs or other pharmaceuticals.
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Health, family and romance problems appear to be the particular life stressors most associated with increased risk for using opioids to cope, and individuals with low self-esteem appear to be at risk for these connections. The research team, which included Binghamton University graduate student Damla Aksen, surveyed 1,000-plus adults about five life stressors, self-esteem, and indications of opioid use.
Examining the data, they found that poor self-esteem was associated with high opioid use and that poor self-esteem was a significant mediator between each life stressor (health, family, romance) and increased risk for opioid use. The study was published in the Journal of Drug Issues.
The evidence is mounting that a poor diet plays an important role in the development of age-related macular degeneration (AMD), a leading cause of blindness in the United States
Patients with chronic obstructive pulmonary disease (COPD) who have comorbidities are more likely to experience readmission or mortality and less likely to receive beneficial treatments, according to a study published in the September issue of the Annals of the American Thoracic Society.
A brief tool assessing emergency department (ED) threat perceptions has clinical utility for providers to identify patients at risk for developing cardiac-induced PTSD and is critical to inform research on whether threat may be modified in-ED to reduce post-traumatic stress disorder (PTSD) incidence. That is the finding of a study to be published in the October 2018 issue of Academic Emergency Medicine (AEM), a journal of the Society for Academic Emergency Medicine (SAEM).
Mesenchymal stem cells (MSCs) are a promising cell source, easy to harvest and differentiate into a variety of mesodermal tissues including fat, bone and cartilage in regenerative medicine. However, for in vivo implantation, a large quantity of stem cells is required with extensive in vitro cell culture to ensure the success of cell-based therapies
A clinical trial to find a better treatment for severe or chronic cases of post kala-azar dermal leishmaniasis (PKDL) in Africa has begun in Dooka, Sudan. The objective of this clinical trial, which is being conducted by the Drugs for Neglected Diseases initiative (DNDi), a non-profit research and development organization, and the Institute for Endemic Diseases (IEND) at the University of Khartoum, is to shorten the length of hospitalization for PKDL and deliver a treatment that is safer to use and easier to administer.
The new lotion spreads easily and is quickly absorbed by the skin, making it an attractive option for many patients suffering from acne. The U.S. Food and Drug Administration has approved Ortho Dermatologic’s new drug application for Altro (tretinoin 0.05%) lotion for the treatment of acne vulgaris.
Approved for use in patients ages nine and older, the formulation is the first of its kind in a lotion, according to a company news release. It is expected to be on the market by the fourth quarter of 2018.
A systematic review of the literature into the effects of caffeine on breastfed infants has concluded that there is no robust evidence for positive or negative effects of maternal caffeine consumption during breastfeeding on a breastfed child—according to Dr. Yen-Fu Chen and graduate-entry medical student Aimee McCreedy of the Warwick Medical School