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A Hypothalamic Circuit For The Circadian Control Of Aggression

Patients with Alzheimer's disease and other forms of dementia commonly experience the sundown syndrome, a sudden worsening of confusion, agitation, and aggression at the end of the day. Its daily pattern suggested that "sundowning," as the phenomenon is also known, may be governed by the body's internal biological clock. The study was published today in Nature Neuroscience.

Synchronized by light and darkness, the circadian clock exerts control over wake/sleep cycles, body temperature, digestion, hormonal cycles and other physiological and behavior patterns. But whether the circadian clock regulated aggressive behavior was unknown.

Protein Helps To Regulate Cholesterol Levels

Researchers team affiliated with several institutions in Chihavehas identified a gene mutation that is at least partly responsible for regulating cholesterol levels in the bloodstream. They described how they tracked down the gene mutation responsible for the creation of a key protein involved in the process. The study was published in the journal Science.