All news from Anaesthesiology

Breathing After Spinal Cord Injury Restored

One of the most severe outcomes of spinal cord injury from car accidents, sports impacts, or other neck trauma, is losing the ability to control breathing, with patients often requiring artificial ventilation for the rest of their lives. Researchers recently tested a hydrogel that releases a nerve-protecting agent at the site of injury, restoring independent breathing in rat models.The work was published in the The Journal for Neuroscience.

Phosphoproteomic Analysis Of The Molecular Substrates Of Sleep Need

Long periods of waking can lead to cognitive impairment, and the need to sleep continues to build up. Sleep then refreshes the brain through alterations in molecular biochemistry. These changes impact neuronal plasticity and brain function, but the molecular underpinnings of "sleepiness" are not well understood. The study was published in Nature.

Local Anesthetic Drug Does Not Reduce Opioid Prescriptions

Researchers suggest, the local anesthetic drug, liposomal bupivacaine, did not reduce in-hospital opioid prescriptions or opioid-related complications in patients who received the drug during total knee replacement surgery as part of a multimodal approach to managing postsurgical pain. The study was published in Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists (ASA).

Periodontium Formation Using Periodontal Ligament Cell Sheet

Researchers used periodontal ligament (PDL)-derived stem cells to create a cell sheet, attached it to a titanium implant, and transplanted it into the mandibular bone of a dog, demonstrating the formation of a periodontal-like structure containing both cementum- and PDL-like tissue. The study, which shows the feasibility of combining a regenerative cell sheet with a titanium dental implant. The study was published in Tissue Engineering.