Patient age correlates with response to immunotherapy in melanoma and depleting regulatory T cells in young patients might have a therapeutic potential to enhance response in younger patients, according to research from The Wistar Institute.
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One of the most severe outcomes of spinal cord injury from car accidents, sports impacts, or other neck trauma, is losing the ability to control breathing, with patients often requiring artificial ventilation for the rest of their lives. Researchers recently tested a hydrogel that releases a nerve-protecting agent at the site of injury, restoring independent breathing in rat models.The work was published in the The Journal for Neuroscience.
Researchers from the Gutenberg Health Study at the Medical Center of Johannes Gutenberg University Mainz participated in this study, which identified 161 genetic factors for myopia
Long periods of waking can lead to cognitive impairment, and the need to sleep continues to build up. Sleep then refreshes the brain through alterations in molecular biochemistry. These changes impact neuronal plasticity and brain function, but the molecular underpinnings of "sleepiness" are not well understood. The study was published in Nature.
The World Health Organization (WHO) recently certified Paraguay as having eliminated malaria, the first country in the Americas to be granted this status since Cuba in 1973.
Researchers suggest, the local anesthetic drug, liposomal bupivacaine, did not reduce in-hospital opioid prescriptions or opioid-related complications in patients who received the drug during total knee replacement surgery as part of a multimodal approach to managing postsurgical pain. The study was published in Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists (ASA).
Nearly one-third of patients with primary biliary cholangitis who had an inadequate response to ursodeoxycholic acid alone achieved a complete biochemical reaction with the addition of bezafibrate to treatment.
Pulling fans into an emotionally connected group atmosphere can enhance brand recall and may secure repeat attendance. That's the key message of a study that analyzed the feelings of fans at a six-day, biannual international track-and-field event.
When first learning to drive, young adults with autism spectrum disorder (ASD) have more difficulty with basic driving skills compared to those with typical development (TD), reports a study in the Journal of Developmental & Behavioral Pediatrics
Researchers used periodontal ligament (PDL)-derived stem cells to create a cell sheet, attached it to a titanium implant, and transplanted it into the mandibular bone of a dog, demonstrating the formation of a periodontal-like structure containing both cementum- and PDL-like tissue. The study, which shows the feasibility of combining a regenerative cell sheet with a titanium dental implant. The study was published in Tissue Engineering.