Tommy John surgery, or reconstruction of the ulnar collateral ligament (UCL) in the elbow, has been dubbed an epidemic among Major League Baseball pitchers. A mechanical engineer at Washington University in St. Louis plans to develop a bioinspired imaging technique to study how damage accumulates in the UCL during loading, or the stress of activating the ligament. This could provide insight into what is progressively happening to these soft tissues when pitchers throw fastballs dozens of times during a game.
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Swiss drugmaker Roche's hopes of having the first immunotherapy cocktail to be approved as an initial treatment for an aggressive form of lung cancer remained intact after a trial showed positive survival data.
Smell and taste disorders, including anosmia, complete loss of the sense of smell it occurs in more than 12% people worldwide. These 'invisible' disorders affect patients' quality of life and health due to the inability to appreciate food flavor.
In a consulting room in Togo's capital, Lome, Geraldo Emmanuel—handicapped since birth six years ago—waits patiently on a bed while a digital scan is taken of his right leg. Thanks to new 3D technology, he may be able to walk normally within a few months.?????
Distribution of single doses of the oral antibiotic ciprofloxacin to residents of rural villages in the African meningitis belt reduced the number of meningitis cases during a 2017 meningitis epidemic, according to a new study in PLOS Medicine by Matthew Coldiron and colleagues from Epicentre and Médecins Sans Frontières in France, Switzerland and Niger.
Researchers show the presence of exosomes in the inner ear and to characterize the changes in their protein content in response to ototoxic medications. Exosomes are nanovesicles involved in intercellular communications. They are released by a variety of cell types; however, their presence in the inner ear has not been described in the literature.
The study is to determine if exosomes are present in the inner ear and, if present, characterize the changes in their protein content in response to ototoxic stress. In this laboratory investigation, inner ear explants of 5-day-old Wistar rats were cultured and treated with either cisplatin or gentamicin. Hair cell damage was assessed by confocal microscopy. Exosomes were isolated using ExoQuick, serial centrifugation, and mini-column methods.
Approximately half of the patients with chronic lymphocytic leukemia (CLL) who relapse after treatment with ibrutinib (Imbruvica, Pharmacyclics) show acquired mutations in the Bruton's tyrosine kinase (BTK) gene.
A recent study suggests that an easy-to-use, non-invasive method can produce reproducible estimates of arterial stiffness in adolescents aged 16-19 years. The results of the study, conducted at the University of Jyväskylä, were published in the journal Clinical Physiology and Functional Imaging
In youth with impaired glucose tolerance or recent-onset type 2 diabetes, neither initial treatment with long-acting insulin followed by the drug metformin nor metformin alone preserved the body's ability to make insulin. The study was published online June 25 in Diabetes Care.
In a randomized, Phase II trial led by researchers at The University of Texas MD Anderson Cancer Center, adding the PARP inhibitor veliparib to a standard chemotherapy agent improved overall response rates (ORR) in patients with small cell lung cancer (SCLC).
Researchers also identified a select group of patients—those whose tumors expressed SLFN11— who also saw a progression-free survival (PFS) and overall survival (OS) benefit, suggesting a promising biomarker for the PARP-inhibitor sensitivity in SCLC.
In a study published in Stem Cell Reports, a McGill team of scientists led by Dr. Carl Ernst, the researcher at the Douglas Hospital Research Centre, revealed a molecular mechanism that may play a role in the development of autism
The bacterium Vibrio cholerae was discovered more than 150 years ago but remains as one of the main causes of bacterial infectious disease globally, especially in low-income nations where it occurs endemic, and outbreaks of cholera disease can lead to major epidemics.