All news from Anaesthesiology

Investigation Of intestinal Mucosal Barrier Functions To Simulated Weightlessness

Researchers examined the responses of intestinal mucosal barrier functions to simulated weightlessness, by using the hindlimb unloading rats model. Exposure to microgravity or weightlessness leads to various adaptive and pathophysiological alterations in digestive structures and physiology. 

Compared with normal controls, simulated weightlessness damaged the intestinal villi and structural integrity of tight junctions, up-regulated the expression of pro-apoptotic protein Bax while down-regulated the expression of anti-apoptotic protein Bcl-2, thus improved the intestinal permeability. It could also influence intestinal microbiota composition with the expansion of Bacteroidetes and a decrease of Firmicutes.

New Era In Cardiology; D-transposition Of The Great Arteries

TGA is a congenital heart defect in which the two major arteries leaving the heart, the pulmonary artery and the aorta, are connected to the wrong ventricles. The result is that oxygenated blood in the lungs is pumped back to the lungs instead of around the body. Blood in the body continues circulating instead of going to the lungs to pick up oxygen. The study was published in Cardiovascular Innovations and Applications.

Nucleus Tuberalis Lateralis Plays A Vital Role In Regulating Eating Behavior

A team of researchers from China and Singapore has discovered a region in the brain that appears to play a central role in regulating eating behavior. In their paper published in the journal Science, the group describes their study of the brain region and what they found. Sabrina Diano with the Yale University School of Medicine offers a Perspective piece on the work done by the team in the same journal issue