All news from Anaesthesiology

To Quantify Drug-Target Interaction Using Fluorescence Endomicroscopy

Scientists have developed a technique that allows them to measure how well cancer drugs reach their targets inside the body. It shows individual cancer cells in a tumor in real time, revealing which cells interact with the drug and which cells the drug fails to reach. The study was published in Nature Communications. They could help clinicians decide the best course and delivery of treatment for cancer patients.

Delivery Of Proapoptotic Peptide To Cancer Cells

Researchers discovered a cyclic decapeptide that serves as a promising lead compound as a new intracellular delivery vehicle for therapeutically effective peptides. The bottleneck of cationic antimicrobial peptides as anticancer therapeutics is their limited ability to penetrate cell membranes.

When conjugated with another membrane impermeable proapoptotic domain (PAD) peptide, the compound was found to have significant inhibitory activity in cancer cell lines. The study was published in Bioconjugate Chemistry.

'The Pediatric Asthma Yardstick': New Approach in Asthma Management

Although about 10% of school-aged children in the United States have asthma, there are few comprehensive U.S. guidelines for treating pediatric asthma. The Pediatric Asthma Yardstick, a new guideline from the American College of Allergy, Asthma, and Immunology (ACAAI), offers a user-friendly "operational document". It helps healthcare professionals understand which controller treatments are right for which age groups and identifies when a step up is needed.

Anatomy Of Foot And Thier Parts

A study showing that the foot diagram has a complex structure made up of bones, ligaments, muscles, and tendons. Understanding the structure of the foot is best done by looking at a foot diagram where the anatomy has been labeled.

Foot Regions

Foot Bones can be divided into different regions: anterior, posterior, dorsal, plantar, distal, proximal, medial, and lateral. Another way of talking about foot bones is by dividing them into tarsal bones, metatarsal bones, and phalanges. In this article, we will use this classification for the sake of clarity and simplicity.

There are 33 different joints in the foot. The joints are made up of two bones coming together but they also involve tendons, ligaments, and muscles. There are 28 different bones and more 100 tendons in the foot.

Occurrence and Treatment of Brain Metastases in ROS1 Lung Cancer

Increasingly, doctors are treating lung cancer based on the genetic rearrangements driving the disease. For example, cancers that are driven by changes in the genes ALK,EGFR, and ROS1 can now all be paired with drugs that target these specific changes.

However, these cancers are not only dangerous in the lung where they appear, but can become especially dangerous if they are able to metastasize to the brain – a common cause of death from lung cancer. And some targeted treatments work better than others against cancer that has spread to the brain.

Astronauts Occupied With Their Duty In ISS

Astronauts are expected to conduct a wealth of experiments on the International Space Station (ISS). They also have a lot of other tasks, like maintenance work. Even astronauts get time off in space. An astronaut's working day is not so different from that on Earth. Of course, it is a unique environment, but they work eight hours, sometimes nine or ten hours if a job requires overtime, just like in normal life.

Compulsive Sexual Behavior Considered As A Mental Illness

A new study showed that the World Health Organization has recognized "compulsive sexual behavior" as a mental disorder but said Saturday it remained unclear if it was an addiction on a par with gambling or drug abuse. The contentious term "sex addiction" has been around for decades but experts disagree over whether the condition exists.

In the latest update of its catalog of diseases and injuries around the world, the WHO takes a step towards legitimizing the concept, by acknowledging "compulsive sexual behavior disorder", or CSBD, as a mental illness.