All news from Anaesthesiology

New Research Program Streamlines Clinical Trials for Brain Disorders

The Network for Excellence in Neuroscience Clinical Trials, or NeuroNEXT, a research program that helps streamline Phase II clinical trials for brain disorders, has been renewed for five more years, with several new centers joining the program. NeuroNEXT is supported by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health.

Enzymes Bifurcation Revealed By Mass Spectrometry

Scientists have used the atomic resolution structural models of proteins from X-ray crystallography, nuclear magnetic resonance spectroscopy, and more recently cryo-electron microscopy. However, not all proteins relent to structural analyses using these approaches, and as the depth of knowledge increases, additional data elucidating a mechanistic understanding of protein function is desired. 

Protein Complex Identifies Patients Develop Resistance To Anti-Cancer Drugs

Researchers have identified a protein complex that might explain why some cancer patients treated with the revolutionary new anti-cancer drugs known as PARP inhibitors develop resistance to their medication. They showed that Shieldin so called because it shields the ends of broken DNA regulates DNA repair and could be a useful marker for identifying which patients are likely to respond poorly to PARP inhibitors. The study was published in Nature Cell Biology.

Hormone Alleviates the Effect of Chemotherapy for Lung Cancer

A naturally occurring hormone could help make chemotherapy much more effective for many Australians with lung cancer, according to new findings from Sydney and Melbourne researchers. And the hormone—known as follistatin—also appears to prevent kidney damage, a serious side effect of chemotherapy.