All news from Anaesthesiology

New Forms in The Circadian Clock

A long-studied factor controlling human sleep cycles actually has two forms, one that keeps a key protein stable and another that promotes its degradation. From the heart and lungs that propel our blood to our rumbling stomachs at lunchtime and a feeling of tiredness in the evening, our bodies keep steady rhythms day in and day out.

This 'circadian clock' is a series of tightly controlled cycles of specific amounts of proteins that make us either sleepy or wakeful. It has recently attracted public attention with the 2017 Nobel Prize for Physiology or Medicine, but numerous aspects of the clock's functions or how it regulates our health remain a mystery.

Sepsis Caused by Staph Leads to Serious Damage, Mechanism Uncovered

For patients diagnosed with a Staphylococcus aureus infection, often referred to as a staph or MRSA infection, every minute counts. The bacteria create havoc in the body. The immune system goes into overdrive. The heightened immune response can lead to sepsis, which kills 30 to 50% of the people who develop it. In Canada, sepsis is the 12th leading cause of death.

Combination Of Drugs Receives Opinion For Treating Melanoma

Pierre Fabre today announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion recommending approval of BRAFTOVI® (encorafenib) and MEKTOVI® (binimetinib) in combination for the treatment of adult patients with unresectable or metastatic melanoma with a BRAFV600 mutation. 

The CHMP recommendation will now be reviewed by the European Commission (EC), which has the authority to approve medicines for the European Union (EU). "We are delighted to be one step closer to bringing BRAFTOVI and MEKTOVI to patients with advanced BRAF-mutant melanoma in Europe. If the European Commission approves BRAFTOVI and MEKTOVI, this will be a new treatment option for these patients who currently have a challenging prognosis.