All news from Anaesthesiology

Positive Opinion for Treating Cystic Fibrosis

Vertex Pharmaceuticals (Europe) Limited announced that the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion for SYMKEVI® (tezacaftor/ivacaftor) in a combination regimen with ivacaftor (KALYDECO®) for the treatment of people with cystic fibrosis (CF) aged 12 and older.

Those who either have two copies of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, or one copy of the F508del mutation and a copy of one of the following 14 mutations in which the CFTR protein shows residual activity: P67L, R117C, L206W, R352Q, A455E, D579G, 711+3A→G, S945L, S977F, R1070W, D1152H, 2789+5G→A, 3272-26A→G, and 3849+10kbC→T.

Drug System Could Target 'Undruggable' Enzymes Severe In Diseases

Scientists demonstrated the capabilities of the new system by identifying a molecule that could successfully target a phosphatase to reduce the accumulation of Huntington's disease-associated proteins in the brains of mice. A new drug discovery system allows scientists to specifically target members of an important family of enzymes, called phosphatases, which were previously considered mostly "undruggable". The study was published in Cell, could enable scientists to screen for drugs that can target specific phosphatases.

Medical History Online Important in Healthcare in India

Our data is constantly being collected and harvested—a breach of privacy most recently uncovered through political plots. One can’t Google a product or service without it showing up later, baiting you through advertisements and sponsored posts. I understand why the idea of data being stored insidiously has become a scary, almost dystopic thought. But I’ve always felt is that one sector underutilizes data and for the worst possible reason.

Anatomy And Physiology of The Heart

A study estimated that the heart is a type of muscle whose primary responsibility is to pump blood throughout the circulatory system. This system consists of many veins and blood vessels that branch out even to the smallest organs, ensuring that all parts of the body are consistently given enough supply of oxygen to function efficiently. Without a sufficient supply of oxygen, any bodily function would fail, causing organ damage or organ death.

Faulty Cytoskeleton Impairs Immune Cells

In order to move, a body needs a strong scaffold. This is not only true on a macroscopic level, where animals rely on skeletons to support their muscles. It is also true on a cellular level: The cytoskeleton, composed of actin filaments, is crucial for active movement of the cell.