A phase 3 trial evaluating lenalidomide plus rituximab for the treatment of relapsed/refractory indolent lymphoma met its primary endpoint of PFS compared with rituximab plus placebo, according to the agent’s manufacturer.
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Job numbers declined again for Americans with Disabilities last month, according to today's National Trends in Disability Employment—Monthly Update (nTIDE), issued by Kessler Foundation and the University of New Hampshire's Institute on Disability (UNH-IOD). Despite the second month of downturns, experts remain optimistic about future job gains as the labor market continues to tighten
The global age-standardized lung cancer mortality rate among women is projected to increase by 43% from 2015 to 2030, according to an analysis of data from 52 countries. The global age-standardized breast cancer mortality rate is projected to decrease by 9% in the same time frame. The study is published in Cancer Research.
The aim of the study is to retrospectively analyze the cough status after double lumen tube (DLT) and spontaneous respiration thoracic anesthesia, to compare the degree of influence of anesthesia and surgical factors, and to investigate whether spontaneous respiration anesthesia can reduce the incidence of a cough.
MRI interrater reliability is superior to that of radiographs which demonstrated a significant proportion of both false negative and false positive findings for global sacroiliitis impression among juvenile patients, according to findings published in Arthritis Research & Therapy.
Researchers at Case Western Reserve University are using wearable sensor technology to develop an automatic alert system to help people quit smoking.
The cells within a human body are myriad, multi-functioned, and completely distinct from one another. Different kinds of human cells replace themselves at different rates, which means the human body is comprised of cells of many different ages. The vast majority of these cells regenerate fairly rapidly, making most cells in a human body much younger than the age of the human itself.
The researcher behind a groundbreaking study that attempted to date the ages of various cells in a human body, Jonas Frisen, famously estimated that the average age of a cell in the human body is between 7 and 10 years old in a pivotal 2005 paper. The study was published in Cell.
Anaplasmosis, a tick-borne febrile disease, can be carried by wild mammals before being transmitted to humans through a tick bite. Now, researchers reporting in PLOS Neglected Tropical Diseases have found that Anaplasma bacteria alter the patterns of other microbes in the spleens of mice and shrews.
Researchers have found that the enzyme histone deacetylase 1 (HDAC1), normally in the nucleus of cells, is also present in the axons of some neurons. When a degenerative signal is activated, HDAC1 modifies a component of a molecular motor, which then drives a signaling agent down the axon to the neuron’s cell body, killing it.
A biochemistry instructor curious about an enzyme discovered in the damaged neurons of people with multiple sclerosis made a leap toward a potential cure for countless neurodegenerative ills.
Their paper, “Retrograde degenerative signaling mediated by the p75 neurotrophin receptor requires p150glued deacetylation by axonal HDAC1,” appears online today in the journal Developmental Cell.
Johns Hopkins researchers say a heart imaging study of scores of pregnant women with the most severe and dangerous form of a blood pressure disorder has added to evidence that the condition—known as preeclampsia—mainly damages the heart's ability to relax between contractions, making the organ overworked and poor at pumping blood
Keratinocyte skin cells are common targets of the beta subtype of human papilloma virus. This usually harmless infection causes skin disease in people with rare gene mutations.