All news from Anaesthesiology

Circadian Metabolism Reveals Communication Between Organs And Tissue

Researchers have identified a system of communication networks that exist among organs and tissues that regulate metabolism. Findings from their study provide, for the first time, a detailed "atlas" illustrating how the body creates and uses energy, and how imbalances in the networks may impact overall health.

The study was published in the journal Cell. The research reveals the highly coordinated, multi-tissue metabolism underlying the body's circadian rhythms and examines how disruptions in these rhythms such as those caused by high-fat diets induce misalignment among the network clocks and can trigger inflammation, which has been linked to major diseases and can affect lifespan.

Peptide Based Screen Detects Mutations Affecting Protein-Protein Interactions

The seizures typically begin in the first months of life. It often takes years, however, before those suffering from the rare glucose transporter type 1 (Glut1) deficiency syndrome obtain a correct diagnosis. If the disorder goes untreated, affected children experience developmental delay and frequently have neurological problems.

Various defects in one gene underlie the syndrome. They cause the Glut1 protein to lose its function in the cell membrane: the protein no longer transports glucose from the blood into the brain. The study was published in the current issue of the journal Cell

HIV and TB Epidemics: Researchers Work Towards its Prevention and Cure

Currently, South Africa has the largest number of people living with HIV in the world and is also experiencing a dramatically expanded tuberculosis epidemic. These two epidemics are tightly linked, as HIV increases TB risk and disease, and TB is the leading cause of death among people living with HIV. In 2002, the Yale AIDS Program began addressing the twin epidemics in KwaZuluNatal, the country's most populous and heavily burdened province.