All news from Anaesthesiology

Risk Gene For Alzheimer's May Aggravate Neurological Effects of Air Pollution in Children

There is growing evidence that exposure to air pollution adversely affects cognitive and behavioral development in children. However, the mechanisms underlying this association are, as yet, unknown. Now, the findings of a new study from the Barcelona Institute for Global Health (ISGlobal), an institute supported by the "la Caixa" Banking Foundation, suggest that the ε4 variant of the APOE gene may play a significant role in this process

Specilized Neurons For Proper Breathing Rhythms At Birth

The common expression, 'As easy as breathing,' is truly misleading. Breathing, as it is performed by higher vertebrates, is a complex biological function involving many types of neurons. It requires chemosensory neurons to sense oxygen and carbon dioxide levels in the blood and motor neurons to control muscle movement.

It also needs specialized neurons to establish correct breathing rhythms at birth and subsequently maintain it throughout life. The mechanism by which actions of these diverse groups of neurons are finely orchestrated to produce precise breathing rhythms has remained a mystery. The study was published in the journal eLife.

Methylation Of Enzymes Within Peptide Bonds

While chemical methylation of an amide bond uses a strong base to generate the imidate, OphA, the precursor protein of the fungal peptide macrocycle omphalotin A, self-hypermethylates amides at pH 7 using S-adenosyl methionine (SAM) as cofactor.

The peptide bond, the defining feature of proteins, governs peptide chemistry by abolishing nucleophilicity of the nitrogen. This and the planarity of the peptide bond arise from the delocalization of the lone pair of electrons on the nitrogen atom into the adjacent carbonyl.

Association Between High-sensitive Troponin And CV Using CMR

Researchers have now able to show that cardiac damage can be diagnosed in a patient-friendly way by heart imaging- ahead of the clinical symptoms.Systemic inflammatory diseases, such as lupus, often cause cardiac damage that goes undetected.

The number of diagnoses of systemic lupus erythematodes (SLE) has tripled over the past 45 years due in part to improved diagnostic methods. Lupus is a systemic inflammatory disease which can affect several organs; most frequently the kidneys, skin, brain and the heart. Involvement of the heart is important as it determines these patients' outcome, yet as it carries on silently for a long time, it may go undetected and untreated for a long time.

Big Let-up In Obamacare Premiums

Millions of people covered under the Affordable Care Act will see only modest premium increases next year, and some will get a price cut. That is the conclusion from an exclusive analysis of the besieged but resilient program, which still sparks deep divisions heading into this year's midterm elections.

Potential Biomarker For Autism

Investigators at the UC Davis MIND Institute and NeuroPointDX, a division of Stemina Biomarker Discovery, have identified a group of blood metabolites that could help detect some children with autism spectrum disorder (ASD). Part of the Children's Autism Metabolome Project (CAMP), the largest metabolomic ASD study ever attempted, these findings are a key step toward developing an ASD biomarker test. The study was published in the journal Biological Psychiatry.

Emergency Department Implementation Of CDC Brain Injury Guidelines

New evidence-based guidelines, developed by the Centers for Disease Control and Prevention (CDC) with input from the American College of Emergency Physicians (ACEP) and others put forward recommendations for a broad range of health care providers responsible for detection and management of pediatric mild traumatic brain injury, most of which are concussions.

The CDC recommendations are outlined in an Annals of Emergency Medicine editorial and span diagnosis, prognosis, management and treatment in a variety of clinical settings. From 2005-2009, there were almost 3 million emergency visits for pediatric mild traumatic brain injury, according to the CDC.