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Anesthesiology

Cannabis Users Are More Tolerant To Anesthesia Agents

Researchers from Colorado have found that people who regularly use cannabis are more likely to be tolerant to anesthetic agents and may require higher doses to achieve same effects as non users. They also required higher amounts of sedatives to achieve similar sedation as non-users, write the researchers in their study titled; “Effects of Cannabis…

Anesthesiology

Anesthesia Sends Neurons Down In Unborn Rat Babies

While there has long been discussion whether exposure to anesthesia affects brain development, new Rush University Medical Center research published in the journal Cerebral Cortex describes how prenatal anesthesia in rats seems to disrupt the “precisely choreographed” and timed migration of neurons to the area of the developing brain where thinking, memory and language occur. Postnatal…

Anesthesiology

Workings of Ketamine in Depressive Illness Decoded

Anaesthetic drug ketamine has been recently studied in depressive illness that has not responded to standard medication. Researchers have now found the exact mechanism of how the drug works in the brains of individuals with depression and can keep the symptoms down for more than a week. The results of the study titled; “Sustained rescue…

Anesthesiology

Ketamine Reverses Neural Changes Underlying Depression

Researchers have identified ketamine-induced brain-related changes that are responsible for maintaining the remission of behaviors related to depression in mice findings that may help researchers develop interventions that promote lasting remission of depression in humans. The study, funded by the National Institute of Mental Health (NIMH), part of the National Institutes of Health, appears in…

Anesthesiology

Chloroprocaine Offers Adequate Anesthesia for Knee Arthroscopy

Chloroprocaine results in adequate anesthesia with quick recovery of sensory/motor functions for knee arthroscopy in the ambulatory setting, according to a study presented at the Annual Regional Anesthesiology and Acute Pain Medicine Meeting, held from April 11 to 13 in Las Vegas. Elsbeth Wesselink, Pharm.D., and Marcel de Leeuw, Ph.D., from the Zaans Medical Center…

Anesthesiology

Gas Inhalational Anaesthetic and Likelihood of Cancer Return

The team hypothesizes that while undergoing a surgery using gas anaesthetics, those with cancer are at a greater risk of a cancer relapse. There have been previous studies in laboratory mice that have shown this phenomenon to be true. Peter MacCallum Cancer Centre’s Bernhard Riedel is the lead investigator of this study. He assures that this hypothesis…

Anesthesiology

Ketamine Infusions Show Initial, Repeated Depression Benefits

A new study shows that weekly ketamine infusions are associated with continued and maintained reductions in depressive symptoms among patients with treatment-resistant depression. The findings, which are considered novel among studies assessing ketamine administration for patients with treatment-resistant depression; evidence the promising role the controversial drug could play in psychiatric care. Controversial drug A team of…

Anesthesiology

Ketamine-Based Drug to Treat Difficult Cases of Depression

Ketamine, often referred to as “Special K”, is a powerful hallucinogenic drug which, when abused, can help users detach from reality. Long-term ketamine use can have harmful psychiatric effects such as memory loss, decreased sociability, and even permanent psychosis. However; Ketamine is also classify by the Drug Enforcement Agency (DEA) as a Schedule III substance, one with beneficial…

Anesthesiology

Esketamine and Psychedelics Require Restructuring Mental Health

The  Depression roared back with a vengeance: three visits in three weeks to the emergency department of a busy inner-city hospital in downtown Toronto. The third time she was actively suicidal; and is whisk away to the psychiatric crisis unit on the bright and airy fifth floor. I was a medical student at the time;…

Anesthesiology

Immunosuppressant Extend Ketamine's Antidepressant Effects

While exploring the immunosuppressant rapamycin and its potential to block the antidepressant effects of ketamine, researchers serendipitously discovered the drug may actually prolong ketamine’s efficacy. In a small, double-blind crossover study, patients with major depressive disorder (MDD) are treat with either rapamycin or placebo; follow 2 hours later with an infusion of ketamine. Mechanism of action…

Anesthesiology

Intranasal Dexmedetomidine Decreases Barbiturate Requirement

Barbiturates are commonly use in ambulatory sedation of pediatric patients. However, use of barbiturates involve risks of respiratory complications. Dexmedetomidine, a highly selective α2-adrenoceptor agonist, is increasingly use for pediatric sedation. Premedication with intranasal (IN) dexmedetomidine offers a non-invasive and efficient possibility to sedate pediatric patients undergoing magnetic resonance imaging (MRI). Hospital records Our hypothesis…

Anesthesiology

Crucial Receptor Involved In Response to Fast Acting Antidepressants

Effective treatment of clinical depression remains a major mental health issue, with roughly 30% of patients who do not respond to any of the available treatments. Researchers at the University of Maryland School of Medicine (UMSOM) have discovered a crucial receptor called mGlu2 that is critical to the mechanism of fast-acting antidepressants such as ketamine…