New research appear in the journal Current Atherosclerosis Reports showed that Resolvin E1 molecule if applied on gum tissues prevents and treats gum disease as well as decreases the likelihood for advanced arterial atherosclerotic plaques to rupture and form a dangerous thrombus or blood clot.
Resolvin E1 is a molecule produced naturally in the body from an omega -3 fish oil. Previously it was shown that the molecule could be used in the prevention and treatment of gum diseases. The present study reported that the molecule could lead to effective preventive and therapeutic treatments in people with heart disease and/or gum disease without unwanted side effects.
Inflammation is a key pathology of atherosclerosis and may be a major driving force for heart attacks and stroke. There is increasing evidence from numerous research groups that chronic inflammatory diseases including, diabetes, heart disease, rheumatoid arthritis, colitis, pulmonary and kidney diseases, cancer and Alzheimer's disease can benefit by the use of the pro-resolving lipid mediators, resolvins and lipoxins.
The researchers group from Boston University School of Medicine (BUSM) and The Forsyth Institute used two groups of an experimental model that possessed highly inflamed advanced atherosclerosis to test the effectiveness of lipid mediators on advanced atherosclerosis. The first group was treated with a solution applied on gum tissues that contained Resolvin E1 while the second group was treated with salt water as a control.
The group treated with the inflammation-lowering lipid mediator (Resolvin E1) had minimal atherosclerosis and reduced plaque rupture in their aortic artery, while atherosclerosis advanced to more severe form of the disease in the control (salt water) group. Current therapies for advanced atherosclerosis are inadequate and often carry high risks.
The Resolvin E1 therapy could provide a very effective and safe therapy that can be taken daily, which would also serve as a preventive approach for plaque inflammation and acute clinical events of heart attack and stroke, explained corresponding author James A. Hamilton, PhD, professor of physiology and biophysics and research professor of medicine at BUSM.
Moreover, the research team said that the study findings support a paradigm shift in the treatment of both localized and systematic inflammatory conditions that are increasingly prevalent in type 2 diabetes and obesity. The findings might be applicable to other chronic inflammatory diseases, they added.