A new Journal of Obstetrics and Gynaecology Research study offers infertile women new information regarding their expected probabilities of becoming pregnant and may help them select the optimal treatment based on their various risk factors

In an analysis of the medical records of 1,864 female infertile patients in Tokyo from 2000-2015, 49.4% and 21.9% of patients conceived after being treated with assisted reproductive technology (ART) and non-ART, respectively.

ART treatment

Age over 35 years, advanced endometriosis, and a past history or current presence of uterine fibroids had negative impacts on the outcome of non-ART. The effect of advanced endometriosis was especially high for patients in their 30s. ART treatment for patients with advanced endometriosis was effective.

The medical records of 1864 females, infertile patients from January 2000 to December 2015 at our hospital, were retrospectively reviewed under the approval of the Institutional Review Board. They extracted 10 representative factors and calculated the cumulative live birth rate (CLBR) in these patients.

Multivariate analysis of ART and non?ART treatment was performed to assess the impact of infertility factors, and the age?related decline in the cumulative live birth rate was calculated by creating eight age?stratified subgroups.

ART treatments include in vitro fertilization and intracytoplasmic sperm injection, while non-ART treatments include mild ovarian stimulation together with timed intercourse and/or intra-uterine insemination.

Considering that non?ART treatment had a limited role in patients with advanced endometriosis, prompt initiation of ART in these patients aged as young as 30 years can be recommended to achieve conception.

"Some women in their early 30's may be suffering from advanced stage endometriosis and will remain to be infertile unless they are extensively treated," said co-author Dr. Osamu Wada-Hiraike, of The University of Tokyo.