In a study of more than 15,000 girls and their mothers maternal overweight and hyperglycemia were linked to the earlier onset of puberty in girls 6 to 11 years old. Early puberty has been linked to multiple adverse health developments as girls grow up, study finds
The study, "Associations between maternal obesity and pregnancy hyperglycemia and timing of pubertal onset in adolescent girls: A population-based study," was published today in American Journal of Epidemiology. The girls in the study were from diverse cultures and ethnicities.
"We know that maternal weight can influence childhood weight. What we are learning is that the in utero environment may also affect the timing of future pubertal development in offspring, which makes sense since human brains are developed in utero, and the brain releases hormones affecting puberty," said lead author Ai Kubo.
This research builds on previous Kaiser Permanente research that demonstrated earlier onset of puberty in American girls, as well as the possible role of environmental, perinatal and other risk factors. Early youth, including the early onset of breast development or menarche, increases the risk of adverse health outcomes including obesity, type 2 diabetes, polycystic ovarian syndrome, and cancer in adolescence and adulthood.
For girls, it has been linked to a higher risk of adverse emotional and behavioral outcomes including depression, anxiety, earlier sexual initiation, and pregnancy.
In 2010, Kaiser Permanente pediatricians in Northern California began routinely documenting Tanner stages, a standardized measure of pubertal development, in electronic health records during routine pediatric exams. This study is the largest to link the Tanner-stage measurements of girls with the medical records of their mothers to assess the role of pregnancy-related factors on pubertal timing.
Researchers found that maternal obesity and overweight in mothers was associated with 40% and 20% greater chance of earlier breast development in girls, respectively. The study also found a 7-month difference in onset of breast development in daughters of obese versus underweight mothers.
For pubic hair development, similar associations between maternal obesity and earlier onset were found. However, the data suggest that the associations may differ by race and ethnicity. For instance, Asian girls with obese mothers were 50% more likely to experience an earlier onset of pubic hair than Asian girls with normal-weight mothers, while there were no associations among African-American girls.
The study also found a significant relationship between hyperglycemia in mothers and the earlier onset of breast development, but not in mothers with gestational diabetes.
"It's possible that women with the diagnosis of gestational diabetes were more careful about weight and diet, which might have changed the amount of weight gain and offspring development patterns, but other studies need to replicate the finding to be able to conclude that there is an association," Kubo noted.
Senior author Lawrence H. Kushi, ScD, said, "Understanding the intergenerational effects of in utero exposures is helping healthcare systems such as Kaiser Permanente to develop new strategies for assisting women to manage weight and hyperglycemia before and during pregnancy, not only for their health but also for that of their children."