A study found that low amounts of the hormone could also be associated with chronic disease, even among men 40 years of age and younger. A male's total testosterone level may be linked to more than just sexual health and mass muscle preservation. By looking at data for men from a population level, it has become evident over time that chronic disease is on the rise in older males," says Mark Peterson. The study was published in Scientific Reports. They studied this relationship among testosterone, age and chronic disease.

"Previous research in the field has shown that total testosterone deficiency in men increases with age, and studies have shown that testosterone deficiency is also associated with obesity-related chronic diseases," Peterson says. "But it hasn't been previously understood what the optimal levels of total testosterone should be in men at varying ages, and to what effect those varying levels of the hormone have on disease risk across the lifespan."

The study's basis came from previous work from other researchers that appeared to define normal ranges of testosterone but didn't use population-representative cohorts, he says. "Previous studies used clinical cohorts that were not reflective of the current male population in the United States," Peterson says. "The cohorts they used enforced strict guidelines for patients that were accepted into the cohort. Therefore, those patients tended to be much healthier."

Multimorbidity across age groups

Of the 2,399 men in the survey who were at least 20 years old, 2,161 had complete information on demographics (e.g., age, ethnicity and household income), chronic disease diagnoses, blood samples obtained for total testosterone, grip strength and lab results for cardiometabolic disease risk factors.

Researchers then examined the prevalence of nine chronic conditions, including type 2 diabetes, arthritis, cardiovascular disease, stroke, pulmonary disease, high triglycerides, hypercholesterolemia, hypertension and clinical depression. The researchers studied the prevalence of multimorbidity, or when two or more of the chronic conditions were present, among three age groups with and without testosterone deficiency.

The author hopes the study and its results can serve as a public service announcement for men. A lot of men may not be aware of the risk factors for testosterone deficiency because of their current lifestyle. And more importantly, that declining levels could be contributing to a silent decline in overall health and increased risk for chronic disease.

They found that low total testosterone was associated with multimorbidity in all age groups, but it was more prevalent among young and older men with testosterone deficiency."This study showed a robust association between testosterone and multiple medical morbidities that could influence the way we think about testosterone in general practice," Belakovskiy says. "While these findings cannot prove causation, it does spark the need for better clinical awareness and more research."