Anesthesiology

The researches find that the A new study indicates that the antidepressant effects of ketamine may not be such, according to a paper published in Psychotherapy and Psychosomatics. The study investigates the hypothesis that depressed individual receiving ketamine infusions; associate feelings of lightness and floating which are a typical occurrence in the use of psychoactive-substance; with an antidepressant state. Therefore Ketamine is use by medical practitioners and veterinarians as an anaesthetic. It is sometimes use illegally by people to get high.

Antidepressant effects of ketamine

Ketamine can produce psychedelic effects, causing a person to see, hear, smell, feel or taste things that aren’t really there or are different from how they are in reality. When it’s sold illegally; ketamine usually comes as a white crystalline powder. It can also be make into tablets and pills, or dissolved in a liquid. A number of clinical trials and studies are currently being undertaken to assess ketamine as a treatment for depression; early indications are showing good results.

Pharmacologically, ketamine is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, but at higher doses may also bind to the opioid mu and sigma receptors. This drug disrupts the neurotransmitter (brain chemical) glutamate. Glutamate is involve with learning, memory; emotion, pain recognition. It can exhibit sympathomimetic activity which can lead to rapid heart rate and elevated blood pressure. Ketamine is a dissociative anesthetic use in human anesthesia and veterinary medicine. Dissociative drugs are hallucinogens that cause a person to feel detached from reality.

Depressed individuals receiving

Much of the sold on the street has been divert from veterinarians’ offices. Ketamine’s chemical structure and mechanism of action are similar to those of PCP. In a systematic YouTube search of depressed individuals using ketamine infusions, 17 out of 62 testifiers (27.4%) spontaneously reported experiencing a sense of lightness or less heaviness that they associated with a reduction in depressive symptoms.

This result is in contrast with the fact that a literature search did not find a single article that addressed the question if a ketamine-induced sense of lightness might be associated with antidepressant benefits for depressed individuals. Furthermore, compared to depressed individuals receiving electroconvulsive therapy (comparison group); but an analog systematic analysis of internet video testimonials shows that antidepressant-associate lightness is rarely report (4%). Authors suggested that future studies should focus on investigating the link between a subjective sense of lightness and antidepressant benefits suggesting a potential role could be played by the -induced opioid-system activation.