In this study, researchers will isolate various compounds from the venom of marine organisms to evaluate their analgesic and anesthetic qualities. This study shows that a multi-disciplinary team of researchers with expertise in biology, anaesthesiology, pharmacology, and medicinal chemistry at U of U Health received a grant from the Department of Defense to identify new, natural compounds to develop non-opioid drugs for pain management.
The approximately $10 million grant will be distributed over four years. Chronic pain lingers, affecting the patient long after an injury has healed. With few options, patients often turn to opioids and anti-inflammatory drugs that work through a limited number of molecular pathways and require increasingly higher doses to continue the analgesic effect.
"Societal dependence on opioid drugs has created an urgent need to find alternatives to these medications to treat chronic pain," said J. Michael McIntosh, M.D., professor of psychiatry at U of U Health and contributor to this project. "This project turns to ocean organisms to identify the next generation of therapeutic pain medications."
More than 10,000 species of sea snails, slugs and other marine molluscs roam the ocean. These organisms lack arms, nets or teeth. Despite these deficiencies, they are effective predators, having evolved an array of venoms to numb, stun and eventually subdue prey. Beyond compound discovery, the team will also explore underutilized biological pathways to reduce the sensation of pain and inflammation.
The aim is to identify novel drugs that have the beneficial effects of opioids, but lack the adverse actions. The researchers will evaluate the candidate compounds identified in this study using three rodent models that mimic chronic pain in humans to evaluate their effectiveness for future clinical trials.
The potential compound identified from C. regius will be taken one step further in this larger study. The team aims to develop a stable drug that can be metabolized in the body and can elicit the analgesic effect, like opioids for chronic pain. "We really hope that we will find a drug that could be as effective for severe pain as opioids but has far less side effects and is not addictive," Teichert said.
The team is building on their previous success in which a compound was isolated from the venom of the cone snail C. magus that inhibits pain by blocking calcium channels. The isolated compound was developed into the drug Prialt, which was approved by the FDA in 2004 to treat severe pain resulting from cancer, AIDS, failed back surgery and certain nervous system disorders. The drug has restricted application as it must be administered by a doctor directly into the fluid surrounding the spinal cord.