Researchers from The Sports Science Center at Texas Christian University, Texas Health Sports Medicine, and the University of Wisconsin-La Crosse evaluated the usefulness of biomarker testing in determining the potential extent of brain trauma suffered from repetitive subconcussive head impacts
Their findings are reported today in the Journal of Neurosurgery, in the article "Fluctuations in blood biomarkers of head trauma in NCAA football athletes over the course of a season" by Jonathan M. Oliver, Ph.D., and colleagues.
In American football, athletes are regularly subjected to subconcussive head impacts—hits to the head that is not severe enough to cause a concussion or even produce a clinical symptom.
To protect contact-sport athletes throughout the football season, Oliver and colleagues call for the development of a simple, easy-to-use, diagnostic test to identify and monitor the accumulation of sub-concussive head impacts. The authors suggest periodic measurement of biomarkers of subconcussive head trauma.
In this study, Oliver and colleagues developed a schedule of blood sampling that is cost effective and could fit into the busy schedule of an academic football program. To test the feasibility of this method, they evaluated the usefulness of two well-known biomarkers of head trauma and more severe traumatic brain injury: the tau protein and neurofilament light polypeptide (NF-L).
The researchers obtained blood samples from thirty-five NCAA football players on seven different days, beginning before fall camp commenced and ended three weeks after the competitive football season had finished.
The researchers wanted to examine fluctuations in plasma concentrations of tau and serum concentrations of NF-L over the course of the entire football season, during which the number and magnitude of head impacts varied.
Those athletes who sustained a concussion were not further examined. The timing of blood sampling was coordinated with the convenience of players and coaches. During the competitive period, this was usually between 36 and 72 hours after a game or practice session.
Twenty football players were identified as starters and fifteen as non-starters. Since starters are involved in more repetitive plays than nonstarters and are consequently more likely to sustain a greater number of head impacts, the researchers expected to see increased concentrations of biomarkers of brain trauma in starters than in nonstarters, who served as controls in this study.
Analyses of the blood samples showed that tau concentrations decreased over the course of the competitive season, compared to preseason values, in both starters and nonstarters. Concentrations did not increase to preseason values until after the competitive season was over.
Statistical analysis showed that differences in tau concentrations between the two groups of athletes (starters and non-starters) were not great enough to differentiate between starters and nonstarters. In this study, tau concentrations were not useful in determining injury due to repetitive subconcussive head impacts.
Statistical analysis showed that during periods of repetitive head impacts, differences in NF-L concentrations demonstrated fair to modest accuracy for differentiating between starters and nonstarters.
The researchers conclude that, in this preliminary study, serum NF-L shows some promise as a sensible and reliable biomarker of brain injury due to repetitive subconcussive head impacts. However, they point out that this study is preliminary and that additional, larger studies should be performed to verify this.
Researchers believe that the knowledge gained by studies of biomarkers will "lay the groundwork for the eventual development of clinical tools to help reduce the deleterious effects of repetitive subconcussive impacts."
When asked about this study, Dr. Oliver responded, "Given recent findings indicating a potential link between repetitive subconcussive impacts and the development of CTE, efforts to determine the effect of subconcussive impacts throughout an athlete's career may prove useful, especially if those efforts are fecost-effectivet effective."