An estimated 120 million people worldwide are infected with lymphatic filariasis, a parasitic, mosquito-borne disease that can cause major swelling and deformity of the legs, a condition known as elephantiasis. Health-care workers rely on leg measurements to assess the severity of the condition. However, measuring legs that are severely swollen often proves cumbersome and impractical.

St. Louis et al. in Sri Lanka, have shown that a portable scanning device can measure limb enlargement and disfigurement faster and more easily in patients with elephantiasis. The research tool makes it easy to obtain accurate measurements and determine whether treatments to reduce swelling are effective. The study is published online in The American Journal of Tropical Medicine and Hygiene.

"This is important because it will allow doctors and researchers to take very accurate limb measurements in developing nations, where there are often limited tools to monitor swollen limbs," said senior author Philip J. Budge.

Portable 3-D scanner, the device is essentially an infrared sensor, mounted on an iPad, that produces a highly accurate, virtual 3-D reconstruction of the legs using scanning technology similar to that found in Microsoft's Xbox Kinect video game system. It was created by Atlanta-based startup LymphaTech to measure lymphedema that sometimes develops in cancer patients after lymph nodes are removed during surgery.

Budge and Ramakrishna Rao teamed up with international partners to test the device on 52 patients with varying stages of lymphedema at a clinic in Galle, Sri Lanka.They compared scanner results with results from two other techniques used to ascertain the severity of elephantiasis: use of a tape measure, and water displacement.

"This is the gold standard for measuring limb volume, but it is cumbersome and impractical to use in field studies," Budge said. "Some patients have lymphedema so severe, they have difficulty getting a leg into the water tank or standing still long enough for all the water to drain out. Or they may have open wounds that complicate the process."

The study showed that the infrared scanner provided measurements of leg volume and of limb circumference at multiple points that were just as accurate and precise as those obtained by tape measure and water displacement.

"But the most encouraging news is that the scanner produced highly accurate results in only a fraction of the time of the other tests," Budge said. Researchers found that the average time required for scanner measurements of both legs was 2.2 minutes. In comparison, the tape measure and water displacement methods took an average of 7.5 minutes and 17.4 minutes, respectively.

"The scanning tool also offers convenience," Budge said. "Many patients with swollen limbs often have great difficulty traveling from their homes to the clinic to have their measurements taken. The scanner should make it possible to take extremely accurate limb measurements in the patients' homes or villages, without cumbersome equipment or inconveniencing patients.

"To our knowledge, this is the first time that infrared 3-D scanning technology has been used in patients with filarial lymphedema," he added. "It worked so well that it has been added as a measurement tool in a future clinical trial in which we are collaborating."