A recent study conducted at the University of Tampere, Tampere University of Technology, Pirkanmaa Hospital District and Fimlab in Finland has concluded that an electronic nose (eNose) can be used to identify the most common bacteria causing soft tissue infections.
An electronic nose (eNose) is a device that mimics the working principle of the mammalian olfactory system. It consists of an array of nonselective sensors, preprocessing electronics and a computer that interprets sensor signals by pattern detection.
The eNose is designed for qualitative, but not quantitative analysis, which enables it to analyze complex mixtures that would be unanalyzable with more sensitive methods such as gas chromatography-mass spectrometry without extensive preparation.
It is affordable, basically maintenance-free, and does not require extensive sample preparation. The eNose can be used to detect the bacteria without the prior preparation of samples, and the system was capable of differentiating methicillin-resistant Staphylococcus aureus (MRSA) from methicillin-sensitive Staphylococcus aureus (MSSA).
Compared to polymerase chain reaction-based methods which only show the presence of the pathogen, eNose also analyzes the potential host’s response to the infection.
Skin and soft tissue infections are common diseases that need medical treatment. Their diagnosis is usually based on bacterial cultures, but in uncomplicated cases, the diagnosis may be made directly based on the clinical presentation of the disease.
However, this may lead to empirical antibiotic treatments, i.e. treatments without a specific diagnosis, which may result in longer treatment times, adverse effects and increased costs.
"Our aim was to create a method for the rapid diagnosis of soft tissue infections. If we had such a method, treatment could be started in a timely manner and targeted to the relevant pathogen directly. This would reduce the need for empirical treatments and shorten diagnostic delays," says doctoral researcher Taavi Saviauk from the Faculty of Medicine and Life Sciences at the University of Tampere.
"The portable eNose device we used does not require laboratory conditions or special training, so it is well suited for outpatient use. The results of this study are a significant step towards our goal," Saviauk continues.
An electronic nose is a device that produces "an olfactory profile" for each molecular compound in the air. The results are analyzed by a computer and the system is programmed to differentiate between different compounds.
The research group conducting the study has previously shown how an eNose can be successfully used to differentiate prostate cancer from benign prostatic hyperplasia using a urine sample and distinguish between the various bacteria that cause urinary tract infections.