According to a new study, reserchers have discovered the effects of aging in our cells could allow doctors to cure or prevent diabetes, fatty liver disease, and other metabolic diseases and possibly even turn back the clock on aging itself. The new finding suggests that fatty liver disease and other unwanted effects of aging may be the result of our cells' nuclei, the compartment containing our DNA getting wrinkly. Those wrinkles appear to prevent our genes from functioning properly.
There's no wrinkle cream for nuclear membranes, but there is a tantalizing possibility: They might use viruses to smooth the membranes' surfaces and restore the cells to functioning as they did in the glow of youth.
The new discovery shows that the location of our DNA inside the cell's nucleus is critically important. Genes that are turned off are shoved up against the nuclear membrane, which encases the nucleus. But with age, our nuclear membranes become lumpy and irregular, and that prevents genes from turning off appropriately.
The accumulation of fat inside the liver can cause serious health effects, increasing the risk of type 2 diabetes and cardiovascular disease, even potentially leading to death. lamin, a cellular protein that comes in various forms. By putting the appropriate lamin back, we might smooth out the membrane, like Retinol helps smooth face wrinkles.
They could use viruses to deliver the shipment. Scientists are already modifying viruses for beneficial medical purposes, and it would be particularly easy to get a modified virus to the liver because of the organ's role in detoxifying the body.
Researcher suspects the wrinkling of the nuclear membrane is responsible for unwanted effects of aging in other parts of the body as well.