A study examined whether MBL deficiency was more frequently present in cases group of tubotympanic CSOM patients rather than healthy subjects. Chronic suppurative otitis media (CSOM) is a common public health problem worldwide and a major cause of hearing impairment, especially in developing countries. The role of Mannose-Binding Lectin (MBL), a component of innate immunity, in CSOM has not been studied. 

CSOM is a common public health problem worldwide and a major cause of hearing impairment, especially in developing countries. The burden of CSOM varies worldwide. The global incidence rate of CSOM was 4.76 per thousand people for a total of 31 million cases.

Hearing Impairment

Global prevalence rates are approximately between 1% and 46%; it has been estimated that 65–330 million individuals have discharging ears, 60% of whom suffered from significant hearing impairment. 

Otitis Media

The occurrence of tubotympanic CSOM is caused by multiple factors such as viral or bacterial infections, tubal dysfunction, allergies, and immunological, environmental, and socioeconomic factors, but bacterial infections that enter the middle ear through nasopharynx was believed to be the most common cause. In addition, bacterial infections also play an important role in the chronicity and recurrence of otitis media.

Several studies that elaborate the role of MBL in health and disease have been published. In the otorhinolaryngology field, research on MBL relationship with some diseases has been done with varying results, such as the research conducted by Homøe et al. which shows that there was no significant relationship between MBL genotype and otitis media.

Role Of Mannose-Binding Lectin(MBL)

On the other hand, a research conducted by Nuytinck et al. suggests that there was a meaningful relationship between MBL genotype with recurrent acute otitis media. However, there were limitations of this study to demonstrate the role of MBL to CSOM, one of which is the relatively small number of samples.

The findings of the current study indicate that having deficient of MBL levels is not a major factor in the pathogenesis of tubotympanic CSOM. However, the presence of subjects with MBL deficiency in the tubotympanic CSOM group might be considered as playing a role in the tubotympanic CSOM.